Detailed information of TA system TA067978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1958367..1958674
• Replicon: chromosome
• Accession: NZ_CP017677
• Organism: Staphylococcus aureus strain CFSAN007894

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: AB466_RS09920
• Protein ID: WP_072353918.1
• Coordinates: 1958498..1958674 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1958367..1958506 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB466_RS09860	1953933..1954112	+	180	WP_000669791.1	hypothetical protein	-
AB466_RS09870	1954423..1954683	+	261	WP_001791826.1	hypothetical protein	-
AB466_RS09875	1954736..1955086	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AB466_RS09880	1955597..1955932	-	336	Protein_1824	SH3 domain-containing protein	-
AB466_RS09900	1956583..1957074	-	492	WP_000920038.1	staphylokinase	-
AB466_RS09905	1957265..1958020	-	756	WP_000861038.1	CHAP domain-containing protein	-
AB466_RS09910	1958032..1958286	-	255	WP_000611512.1	phage holin	-
AB466_RS09915	1958338..1958445	+	108	WP_001791821.1	hypothetical protein	-
-	1958367..1958506	+	140	NuclAT_0	-	Antitoxin
-	1958367..1958506	+	140	NuclAT_0	-	Antitoxin
-	1958367..1958506	+	140	NuclAT_0	-	Antitoxin
-	1958367..1958506	+	140	NuclAT_0	-	Antitoxin
AB466_RS09920	1958498..1958674	-	177	WP_072353918.1	putative holin-like toxin	Toxin
AB466_RS09925	1958817..1959191	-	375	WP_000340977.1	hypothetical protein	-
AB466_RS09930	1959247..1959534	-	288	WP_001262620.1	hypothetical protein	-
AB466_RS09935	1959580..1959732	-	153	WP_001000058.1	hypothetical protein	-
AB466_RS09940	1959725..1963507	-	3783	WP_000582132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1954736..2005726	50990

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T67978 WP_072353918.1 NZ_CP017677:c1958674-1958498 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T67978 NZ_CP017677:c1958674-1958498 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT67978 NZ_CP017677:1958367-1958506 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin