67944

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2774854..2775649 Replicon chromosome
Accession NZ_CP017669
Organism Escherichia coli strain PA20

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag AU473_RS14230 Protein ID WP_000854914.1
Coordinates 2775275..2775649 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag AU473_RS14225 Protein ID WP_001280954.1
Coordinates 2774854..2775228 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AU473_RS14185 2770209..2771114 + 906 WP_000203541.1 chemotaxis protein -
AU473_RS14190 2771111..2772181 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
AU473_RS14200 2772521..2773339 + 819 WP_001234682.1 DUF945 domain-containing protein -
AU473_RS14205 2773430..2773915 + 486 WP_000214398.1 antirestriction protein -
AU473_RS14210 2773931..2774407 + 477 WP_001186738.1 RadC family protein -
AU473_RS14215 2774470..2774691 + 222 WP_001220314.1 DUF987 domain-containing protein -
AU473_RS14225 2774854..2775228 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AU473_RS14230 2775275..2775649 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
AU473_RS14235 2775646..2776137 + 492 WP_000976853.1 hypothetical protein -
AU473_RS14240 2776149..2776346 + 198 WP_000839282.1 DUF957 domain-containing protein -
AU473_RS14245 2776431..2777273 + 843 WP_001280481.1 DUF4942 domain-containing protein -
AU473_RS14255 2777744..2778682 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
AU473_RS14260 2778737..2779474 + 738 WP_000283664.1 zinc-binding phosphatase -
AU473_RS14265 2779498..2780052 + 555 WP_001001917.1 molecular chaperone YcdY -
AU473_RS14270 2780154..2780645 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 2773931..2786213 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T67944 WP_000854914.1 NZ_CP017669:2775275-2775649 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T67944 NZ_CP017669:2775275-2775649 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT67944 WP_001280954.1 NZ_CP017669:2774854-2775228 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT67944 NZ_CP017669:2774854-2775228 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References