Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2042089..2042608 Replicon chromosome
Accession NZ_CP017667
Organism Streptococcus suis strain 1081

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2Z4PLJ8
Locus tag BKM67_RS09935 Protein ID WP_029170938.1
Coordinates 2042089..2042346 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A075STV3
Locus tag BKM67_RS09940 Protein ID WP_029693774.1
Coordinates 2042348..2042608 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKM67_RS09925 2039169..2040899 - 1731 WP_024411119.1 membrane protein -
BKM67_RS09930 2041102..2041974 - 873 WP_105183622.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
BKM67_RS09935 2042089..2042346 - 258 WP_029170938.1 Txe/YoeB family addiction module toxin Toxin
BKM67_RS09940 2042348..2042608 - 261 WP_029693774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BKM67_RS09945 2043283..2043738 - 456 WP_105183623.1 8-oxo-dGTP diphosphatase -
BKM67_RS09950 2043758..2044276 - 519 WP_112435142.1 DUF3916 domain-containing protein -
BKM67_RS09955 2044273..2044875 - 603 WP_162636976.1 ribonuclease M5 -
BKM67_RS09960 2044838..2045620 - 783 WP_105184278.1 TatD family hydrolase -
BKM67_RS09965 2045726..2045863 - 138 WP_002939016.1 50S ribosomal protein L34 -
BKM67_RS09970 2046031..2047026 - 996 WP_013730624.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10267.69 Da        Isoelectric Point: 6.8789

>T67935 WP_029170938.1 NZ_CP017667:c2042346-2042089 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADQLHILSL
KDHYG

Download         Length: 258 bp

>T67935 NZ_CP017667:c2042346-2042089 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTCTACTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAAATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGGTAGAAGCCGACCAGTTGCATATCTTGTCTCTA
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9920.27 Da        Isoelectric Point: 5.1255

>AT67935 WP_029693774.1 NZ_CP017667:c2042608-2042348 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNAYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp

>AT67935 NZ_CP017667:c2042608-2042348 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAAGAAGATATTGTTGTACTGTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTTG
CTGTTGCTCGGAACGCCTACCTATCTCAGAAAGTCTTGCGTGGTATGGCTCAAGTCAAAGCGGGACAAACCCAAGAACGA
AACCTGATAGAGGCAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z4PLJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A075STV3

References