Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1952413..1952932 Replicon chromosome
Accession NZ_CP017666
Organism Streptococcus suis strain 0061

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2Z4PLJ8
Locus tag BKM66_RS09400 Protein ID WP_029170938.1
Coordinates 1952413..1952670 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A075STV3
Locus tag BKM66_RS09405 Protein ID WP_029693774.1
Coordinates 1952672..1952932 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKM66_RS09390 1949493..1951223 - 1731 WP_024411119.1 membrane protein -
BKM66_RS09395 1951426..1952298 - 873 WP_105183622.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
BKM66_RS09400 1952413..1952670 - 258 WP_029170938.1 Txe/YoeB family addiction module toxin Toxin
BKM66_RS09405 1952672..1952932 - 261 WP_029693774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BKM66_RS09410 1953607..1954062 - 456 WP_105183623.1 8-oxo-dGTP diphosphatase -
BKM66_RS09415 1954082..1954600 - 519 WP_112435142.1 DUF3916 domain-containing protein -
BKM66_RS09420 1954597..1955199 - 603 WP_162636976.1 ribonuclease M5 -
BKM66_RS09425 1955162..1955944 - 783 WP_105184278.1 TatD family hydrolase -
BKM66_RS09430 1956050..1956187 - 138 WP_002939016.1 50S ribosomal protein L34 -
BKM66_RS09435 1956355..1957350 - 996 WP_013730624.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10267.69 Da        Isoelectric Point: 6.8789

>T67930 WP_029170938.1 NZ_CP017666:c1952670-1952413 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADQLHILSL
KDHYG

Download         Length: 258 bp

>T67930 NZ_CP017666:c1952670-1952413 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTCTACTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAAATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGGTAGAAGCCGACCAGTTGCATATCTTGTCTCTA
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9920.27 Da        Isoelectric Point: 5.1255

>AT67930 WP_029693774.1 NZ_CP017666:c1952932-1952672 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNAYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp

>AT67930 NZ_CP017666:c1952932-1952672 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAAGAAGATATTGTTGTACTGTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTTG
CTGTTGCTCGGAACGCCTACCTATCTCAGAAAGTCTTGCGTGGTATGGCTCAAGTCAAAGCGGGACAAACCCAAGAACGA
AACCTGATAGAGGCAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z4PLJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A075STV3

References