Detailed information of TA system TA067915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1741158..1741806
• Replicon: chromosome
• Accession: NZ_CP017662
• Organism: Cronobacter sp. JZ38

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BJP61_RS08170
• Protein ID: WP_038861909.1
• Coordinates: 1741158..1741523 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BJP61_RS08175
• Protein ID: WP_038861911.1
• Coordinates: 1741510..1741806 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP61_RS08160	1736564..1739686	-	3123	WP_171998120.1	MdtB/MuxB family multidrug efflux RND transporter permease subunit	-
BJP61_RS08165	1739686..1740927	-	1242	WP_171998121.1	MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit	-
BJP61_RS08170	1741158..1741523	+	366	WP_038861909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJP61_RS08175	1741510..1741806	+	297	WP_038861911.1	XRE family transcriptional regulator	Antitoxin
BJP61_RS08180	1741812..1743164	-	1353	WP_038861914.1	molecular chaperone	-
BJP61_RS08185	1743301..1744149	+	849	WP_171998122.1	DNA-3-methyladenine glycosylase 2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14110.16 Da
• Isoelectric Point: 9.8187

>T67915 WP_038861909.1 NZ_CP017662:1741158-1741523 [Cronobacter sp. JZ38]
MTWTVIFTPHFYEWYQQQPEGLQDRIAALLWNLRHSGPLVGRPLVDTIKGSRIANLKELRVQYGGSPWRVFFAFDPTRQA
VVLCAGNKRGHKDFYKTLITQAETAFFQHLQKIMESKNEND

Nucleotide

• Length: 366 bp

>T67915 NZ_CP017662:1741158-1741523 [Cronobacter sp. JZ38]
ATGACATGGACGGTGATTTTTACCCCGCATTTTTATGAGTGGTATCAACAACAGCCCGAAGGATTACAGGATCGTATCGC
CGCGCTGTTATGGAATTTACGCCACAGCGGCCCGTTGGTTGGGCGTCCGCTGGTGGACACGATAAAAGGCTCGCGGATCG
CCAATCTTAAAGAGCTGCGCGTTCAGTATGGCGGTTCGCCGTGGCGGGTATTTTTTGCCTTCGATCCAACCCGTCAGGCT
GTGGTGCTGTGTGCAGGCAACAAGCGCGGTCACAAAGATTTTTATAAAACCTTAATCACGCAGGCGGAGACGGCGTTCTT
CCAGCATCTGCAAAAAATAATGGAGAGTAAAAATGAAAACGATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10991.91 Da
• Isoelectric Point: 5.2290

>AT67915 WP_038861911.1 NZ_CP017662:1741510-1741806 [Cronobacter sp. JZ38]
MKTIDDVMAEFPPERQAEILRMADEIALEHGLPRLREERAFSQQRLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLVELPEGSKVIPV

Nucleotide

• Length: 297 bp

>AT67915 NZ_CP017662:1741510-1741806 [Cronobacter sp. JZ38]
ATGAAAACGATTGATGATGTGATGGCGGAGTTTCCGCCAGAGCGGCAAGCTGAGATCCTGCGCATGGCTGATGAAATCGC
CCTTGAACACGGGCTGCCGCGCCTTCGCGAAGAAAGGGCGTTCTCGCAGCAGCGGCTGGCGGAGATAATGGGCGTTACGC
AGCCCGCTATCGCCGCCATCGAACAGCGCGGAAAGGAGATCAAACTGCTGACGCTCAAGCGCTATGTCGAAGCGCTGGGC
GGGAAGCTGTCCCTGCTGGTTGAGCTGCCCGAAGGCAGCAAAGTCATTCCTGTTTAA