Detailed information of TA system TA067909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 80230..80888
• Replicon: plasmid unnamed
• Accession: NZ_CP017657
• Organism: Acinetobacter baumannii strain KAB08

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KAB08_RS19480
• Protein ID: WP_000312250.1
• Coordinates: 80529..80888 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KAB08_RS19475
• Protein ID: WP_001096429.1
• Coordinates: 80230..80529 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB08_RS19435	75624..76136	+	513	WP_000840065.1	hypothetical protein	-
KAB08_RS19440	76180..76521	+	342	WP_002001471.1	hypothetical protein	-
KAB08_RS19445	76558..77286	+	729	WP_001022819.1	hypothetical protein	-
KAB08_RS19455	77522..77773	+	252	Protein_87	hypothetical protein	-
KAB08_RS19460	77825..78754	-	930	WP_001091151.1	IS5-like element ISAba10 family transposase	-
KAB08_RS19465	78797..79108	+	312	Protein_89	hypothetical protein	-
KAB08_RS19470	79158..79694	+	537	WP_000731981.1	hypothetical protein	-
KAB08_RS19475	80230..80529	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
KAB08_RS19480	80529..80888	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAB08_RS19485	81089..81655	+	567	WP_041171756.1	hypothetical protein	-
KAB08_RS19490	81704..81886	+	183	WP_000373385.1	hypothetical protein	-
KAB08_RS19495	81953..82651	+	699	WP_000873190.1	hypothetical protein	-
KAB08_RS19500	82790..83173	+	384	WP_000654349.1	hypothetical protein	-
KAB08_RS19505	83240..83998	+	759	WP_001053129.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..101406	101406
	-	flank	IS/Tn	-	-	77825..78754	929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T67909 WP_000312250.1 NZ_CP017657:c80888-80529 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T67909 NZ_CP017657:c80888-80529 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT67909 WP_001096429.1 NZ_CP017657:c80529-80230 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT67909 NZ_CP017657:c80529-80230 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA