Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 83119..83777 Replicon plasmid unnamed
Accession NZ_CP017649
Organism Acinetobacter baumannii strain KAB04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KAB04_RS19685 Protein ID WP_000312250.1
Coordinates 83418..83777 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KAB04_RS19680 Protein ID WP_001096429.1
Coordinates 83119..83418 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAB04_RS19640 78513..79025 + 513 WP_000840065.1 hypothetical protein -
KAB04_RS19645 79069..79410 + 342 WP_002001471.1 hypothetical protein -
KAB04_RS19650 79447..80175 + 729 WP_001022819.1 hypothetical protein -
KAB04_RS19660 80411..80662 + 252 Protein_89 hypothetical protein -
KAB04_RS19665 80714..81643 - 930 WP_001091151.1 IS5-like element ISAba10 family transposase -
KAB04_RS19670 81686..81997 + 312 Protein_91 hypothetical protein -
KAB04_RS19675 82047..82583 + 537 WP_000732006.1 hypothetical protein -
KAB04_RS19680 83119..83418 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
KAB04_RS19685 83418..83777 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAB04_RS19690 83978..84544 + 567 WP_000710385.1 hypothetical protein -
KAB04_RS19695 84593..84775 + 183 WP_000373385.1 hypothetical protein -
KAB04_RS19700 84842..85540 + 699 WP_000873188.1 hypothetical protein -
KAB04_RS19705 85679..86062 + 384 WP_000654348.1 hypothetical protein -
KAB04_RS19710 86129..86887 + 759 WP_001053128.1 hypothetical protein -
KAB04_RS19715 86939..87274 + 336 WP_000653925.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..121485 121485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T67898 WP_000312250.1 NZ_CP017649:c83777-83418 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T67898 NZ_CP017649:c83777-83418 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGTCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTATGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT67898 WP_001096429.1 NZ_CP017649:c83418-83119 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT67898 NZ_CP017649:c83418-83119 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References