Detailed information of TA system TA067891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 44848..45506
• Replicon: plasmid unnamed
• Accession: NZ_CP017643
• Organism: Acinetobacter baumannii strain KAB01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KAB01_RS19145
• Protein ID: WP_000312250.1
• Coordinates: 45147..45506 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KAB01_RS19140
• Protein ID: WP_001096429.1
• Coordinates: 44848..45147 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB01_RS19105	40907..41164	+	258	WP_000834292.1	hypothetical protein	-
KAB01_RS19110	41169..41741	+	573	WP_000429351.1	hypothetical protein	-
KAB01_RS19115	41717..41896	+	180	WP_002081921.1	hypothetical protein	-
KAB01_RS19120	41913..42542	+	630	WP_000701002.1	hypothetical protein	-
KAB01_RS19125	42582..43091	+	510	WP_001043200.1	hypothetical protein	-
KAB01_RS19130	43172..43726	+	555	WP_000790086.1	hypothetical protein	-
KAB01_RS19135	43776..44311	+	536	Protein_55	hypothetical protein	-
KAB01_RS19140	44848..45147	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
KAB01_RS19145	45147..45506	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAB01_RS19150	45707..46273	+	567	WP_000710385.1	hypothetical protein	-
KAB01_RS19155	46322..46504	+	183	WP_000373385.1	hypothetical protein	-
KAB01_RS19160	46571..47269	+	699	WP_000873188.1	hypothetical protein	-
KAB01_RS19165	47408..47791	+	384	WP_000654348.1	hypothetical protein	-
KAB01_RS19170	47858..48616	+	759	WP_001053128.1	hypothetical protein	-
KAB01_RS19175	48668..49003	+	336	WP_000653925.1	hypothetical protein	-
KAB01_RS19180	49871..50368	+	498	WP_000758692.1	J domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..70875	70875

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T67891 WP_000312250.1 NZ_CP017643:c45506-45147 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T67891 NZ_CP017643:c45506-45147 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGTCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTATGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT67891 WP_001096429.1 NZ_CP017643:c45147-44848 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT67891 NZ_CP017643:c45147-44848 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA