67806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2650986..2652229 Replicon chromosome
Accession NZ_CP017602
Organism Legionella pneumophila strain D5945

Toxin (Protein)


Gene name HipT Uniprot ID A0A2S6EXA8
Locus tag BJK08_RS11935 Protein ID WP_027227417.1
Coordinates 2651291..2652229 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S6EX97
Locus tag BJK08_RS11930 Protein ID WP_027227416.1
Coordinates 2650986..2651294 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJK08_RS11895 2646335..2647195 + 861 WP_027227410.1 DUF2608 domain-containing protein -
BJK08_RS11900 2647547..2647811 - 265 Protein_2295 hypothetical protein -
BJK08_RS11905 2647859..2648170 - 312 WP_027227411.1 cupin -
BJK08_RS11910 2648186..2648434 - 249 WP_031301595.1 hypothetical protein -
BJK08_RS11915 2648741..2649214 + 474 WP_027227413.1 hypothetical protein -
BJK08_RS11920 2649404..2650321 + 918 WP_027227414.1 LysR family transcriptional regulator -
BJK08_RS11925 2650762..2650989 + 228 WP_027227415.1 helix-turn-helix transcriptional regulator -
BJK08_RS11930 2650986..2651294 + 309 WP_027227416.1 HipA N-terminal domain-containing protein Antitoxin
BJK08_RS11935 2651291..2652229 + 939 WP_027227417.1 lpg2370 family Dot/Icm T4SS effector Toxin
BJK08_RS11940 2652523..2653686 + 1164 WP_027227418.1 hypothetical protein -
BJK08_RS11945 2653678..2654865 - 1188 WP_027227419.1 fatty acid desaturase -
BJK08_RS11950 2654990..2655157 - 168 WP_011214444.1 DUF3309 domain-containing protein -
BJK08_RS11955 2655756..2656112 + 357 WP_063720028.1 hypothetical protein -
BJK08_RS11960 2656153..2656437 - 285 Protein_2307 hypothetical protein -
BJK08_RS11965 2656481..2657122 - 642 WP_027227422.1 RsmD family RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36142.94 Da        Isoelectric Point: 9.5859

>T67806 WP_027227417.1 NZ_CP017602:2651291-2652229 [Legionella pneumophila]
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD

Download         Length: 939 bp

>T67806 NZ_CP017602:2651291-2652229 [Legionella pneumophila]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11611.39 Da        Isoelectric Point: 4.5556

>AT67806 WP_027227416.1 NZ_CP017602:2650986-2651294 [Legionella pneumophila]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT67806 NZ_CP017602:2650986-2651294 [Legionella pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6EXA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6EX97

References