Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2649338..2650581 Replicon chromosome
Accession NZ_CP017601
Organism Legionella pneumophila strain D6026

Toxin (Protein)


Gene name HipT Uniprot ID A0A2S6EXA8
Locus tag BJK09_RS11930 Protein ID WP_027227417.1
Coordinates 2649643..2650581 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S6EX97
Locus tag BJK09_RS11925 Protein ID WP_027227416.1
Coordinates 2649338..2649646 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJK09_RS11890 2644687..2645547 + 861 WP_027227410.1 DUF2608 domain-containing protein -
BJK09_RS11895 2645899..2646163 - 265 Protein_2296 hypothetical protein -
BJK09_RS11900 2646211..2646522 - 312 WP_027227411.1 cupin -
BJK09_RS11905 2646538..2646786 - 249 WP_031301595.1 hypothetical protein -
BJK09_RS11910 2647093..2647566 + 474 WP_027227413.1 hypothetical protein -
BJK09_RS11915 2647756..2648673 + 918 WP_027227414.1 LysR family transcriptional regulator -
BJK09_RS11920 2649114..2649341 + 228 WP_027227415.1 helix-turn-helix transcriptional regulator -
BJK09_RS11925 2649338..2649646 + 309 WP_027227416.1 HipA N-terminal domain-containing protein Antitoxin
BJK09_RS11930 2649643..2650581 + 939 WP_027227417.1 lpg2370 family Dot/Icm T4SS effector Toxin
BJK09_RS11935 2650875..2652038 + 1164 WP_027227418.1 hypothetical protein -
BJK09_RS11940 2652030..2653217 - 1188 WP_027227419.1 fatty acid desaturase -
BJK09_RS11945 2653342..2653509 - 168 WP_011214444.1 DUF3309 domain-containing protein -
BJK09_RS11950 2654108..2654464 + 357 WP_063720028.1 hypothetical protein -
BJK09_RS11955 2654505..2654789 - 285 Protein_2308 hypothetical protein -
BJK09_RS11960 2654833..2655474 - 642 WP_027227422.1 RsmD family RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36142.94 Da        Isoelectric Point: 9.5859

>T67804 WP_027227417.1 NZ_CP017601:2649643-2650581 [Legionella pneumophila]
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD

Download         Length: 939 bp

>T67804 NZ_CP017601:2649643-2650581 [Legionella pneumophila]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11611.39 Da        Isoelectric Point: 4.5556

>AT67804 WP_027227416.1 NZ_CP017601:2649338-2649646 [Legionella pneumophila]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT67804 NZ_CP017601:2649338-2649646 [Legionella pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6EXA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6EX97

References