Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2974251..2974899 Replicon chromosome
Accession NZ_CP017598
Organism Mycobacterium tuberculosis strain Beijing-like/1104

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BJM04_RS14550 Protein ID WP_003899414.1
Coordinates 2974251..2974574 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BJM04_RS14555 Protein ID WP_003899415.1
Coordinates 2974654..2974899 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM04_RS14520 2969574..2970572 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BJM04_RS14525 2970586..2971050 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BJM04_RS14530 2971038..2971289 + 252 WP_003908028.1 hypothetical protein -
BJM04_RS14535 2971460..2972899 - 1440 WP_003901443.1 phage major capsid protein -
BJM04_RS14540 2972907..2973440 - 534 WP_003899412.1 HK97 family phage prohead protease -
BJM04_RS14545 2973593..2974084 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BJM04_RS14550 2974251..2974574 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BJM04_RS14555 2974654..2974899 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BJM04_RS14560 2974896..2976323 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BJM04_RS14565 2976325..2976717 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BJM04_RS14570 2976714..2976974 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BJM04_RS14575 2976991..2977353 - 363 WP_003900543.1 hypothetical protein -
BJM04_RS14580 2977356..2978483 - 1128 WP_003899420.1 site-specific integrase -
BJM04_RS14585 2978628..2978855 - 228 WP_003899421.1 hypothetical protein -
BJM04_RS14590 2978852..2979241 - 390 WP_003899422.1 hypothetical protein -
BJM04_RS14595 2979147..2979419 + 273 WP_003900544.1 hypothetical protein -
BJM04_RS14600 2979518..2979751 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2969574..2978483 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T67785 WP_003899414.1 NZ_CP017598:c2974574-2974251 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T67785 NZ_CP017598:c2974574-2974251 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT67785 WP_003899415.1 NZ_CP017598:c2974899-2974654 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT67785 NZ_CP017598:c2974899-2974654 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References