Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3546104..3546774 Replicon chromosome
Accession NZ_CP017596
Organism Mycobacterium tuberculosis strain Beijing/391

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag BJM02_RS17390 Protein ID WP_003899954.1
Coordinates 3546104..3546448 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag BJM02_RS17395 Protein ID WP_003899955.1
Coordinates 3546445..3546774 (+) Length 110 a.a.

Genomic Context

BJM02_RS17365BJM02_RS17370BJM02_RS17390BJM02_RS17395BJM02_RS17400BJM02_RS17405BJM02_RS17415BJM02_RS17420BJM02_RS17380BJM02_RS17385BJM02_RS17410BJM02_RS17425
Location: 3541409..3541702 (294 bp)
Type: Others
Protein ID: WP_003416635.1
Location: 3541990..3543279 (1290 bp)
Type: Others
Protein ID: WP_003416640.1
Location: 3546104..3546448 (345 bp)
Type: Toxin
Protein ID: WP_003899954.1
Location: 3546445..3546774 (330 bp)
Type: Antitoxin
Protein ID: WP_003899955.1
Location: 3547312..3547659 (348 bp)
Type: Others
Protein ID: WP_003899956.1
Location: 3547656..3548276 (621 bp)
Type: Others
Protein ID: WP_003899957.1
Location: 3549869..3550078 (210 bp)
Type: Others
Protein ID: WP_003416778.1
Location: 3550113..3550298 (186 bp)
Type: Others
Protein ID: WP_003908177.1
Location: 3544984..3545418 (435 bp)
Type: Others
Protein ID: WP_003899952.1
Location: 3545421..3545873 (453 bp)
Type: Others
Protein ID: WP_003899953.1
Location: 3548436..3549701 (1266 bp)
Type: Others
Protein ID: WP_003902423.1
Location: 3550325..3551359 (1035 bp)
Type: Others
Protein ID: WP_003416786.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BJM02_RS173653541409..3541702+294WP_003416635.1hypothetical protein-
BJM02_RS173703541990..3543279+1290WP_003416640.1ATP-binding protein-
BJM02_RS173803544984..3545418-435WP_003899952.1type II toxin-antitoxin system VapC family toxin-
BJM02_RS173853545421..3545873-453WP_003899953.1type II toxin-antitoxin system Phd/YefM family antitoxin-
BJM02_RS173903546104..3546448+345WP_003899954.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BJM02_RS173953546445..3546774+330WP_003899955.1XRE family transcriptional regulatorAntitoxin
BJM02_RS174003547312..3547659+348WP_003899956.1DUF2384 domain-containing protein-
BJM02_RS174053547656..3548276+621WP_003899957.1RES family NAD+ phosphorylase-
BJM02_RS174103548436..3549701-1266WP_003902423.1hypothetical protein-
BJM02_RS174153549869..3550078+210WP_003416778.1hypothetical protein-
BJM02_RS174203550113..3550298+186WP_003908177.1hypothetical protein-
BJM02_RS174253550325..3551359-1035WP_003416786.1IS30 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T67673 WP_003899954.1 NZ_CP017596:3546104-3546448 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T67673 NZ_CP017596:3546104-3546448 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT67673 WP_003899955.1 NZ_CP017596:3546445-3546774 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT67673 NZ_CP017596:3546445-3546774 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCGGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4FBK2

Antitoxin

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Source
ID
Structure
PDB6LTY
PDB6LTZ
AlphaFold DBG0THF6

References