67605

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2987013..2987661 Replicon chromosome
Accession NZ_CP017595
Organism Mycobacterium tuberculosis strain Beijing-like/38774

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BJM01_RS14630 Protein ID WP_003899414.1
Coordinates 2987013..2987336 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BJM01_RS14635 Protein ID WP_003899415.1
Coordinates 2987416..2987661 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM01_RS14600 2982336..2983334 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BJM01_RS14605 2983348..2983812 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BJM01_RS14610 2983800..2984051 + 252 WP_003908028.1 hypothetical protein -
BJM01_RS14615 2984222..2985661 - 1440 WP_003901443.1 phage major capsid protein -
BJM01_RS14620 2985669..2986202 - 534 WP_003899412.1 HK97 family phage prohead protease -
BJM01_RS14625 2986355..2986846 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BJM01_RS14630 2987013..2987336 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BJM01_RS14635 2987416..2987661 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BJM01_RS14640 2987658..2989085 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BJM01_RS14645 2989087..2989479 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BJM01_RS14650 2989476..2989736 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BJM01_RS14655 2989753..2990115 - 363 WP_003900543.1 hypothetical protein -
BJM01_RS14660 2990118..2991245 - 1128 WP_003899420.1 site-specific integrase -
BJM01_RS14665 2991390..2991617 - 228 WP_003899421.1 hypothetical protein -
BJM01_RS14670 2991614..2992003 - 390 WP_003899422.1 hypothetical protein -
BJM01_RS14675 2991909..2992181 + 273 WP_003900544.1 hypothetical protein -
BJM01_RS14680 2992280..2992513 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2982336..2991245 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-89)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T67605 WP_003899414.1 NZ_CP017595:c2987336-2987013 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T67605 NZ_CP017595:c2987336-2987013 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT67605 WP_003899415.1 NZ_CP017595:c2987661-2987416 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT67605 NZ_CP017595:c2987661-2987416 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References