Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2997714..2998362 Replicon chromosome
Accession NZ_CP017594
Organism Mycobacterium tuberculosis strain Beijing-like/36918

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BJM00_RS14640 Protein ID WP_003899414.1
Coordinates 2997714..2998037 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BJM00_RS14645 Protein ID WP_003899415.1
Coordinates 2998117..2998362 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJM00_RS14610 2993037..2994035 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BJM00_RS14615 2994049..2994513 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BJM00_RS14620 2994501..2994752 + 252 WP_003908028.1 hypothetical protein -
BJM00_RS14625 2994923..2996362 - 1440 WP_003901443.1 phage major capsid protein -
BJM00_RS14630 2996370..2996903 - 534 WP_003899412.1 HK97 family phage prohead protease -
BJM00_RS14635 2997056..2997547 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BJM00_RS14640 2997714..2998037 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BJM00_RS14645 2998117..2998362 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BJM00_RS14650 2998359..2999786 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BJM00_RS14655 2999788..3000180 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BJM00_RS14660 3000177..3000437 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BJM00_RS14665 3000454..3000816 - 363 WP_003900543.1 hypothetical protein -
BJM00_RS14670 3000819..3001946 - 1128 WP_003899420.1 site-specific integrase -
BJM00_RS14675 3002091..3002318 - 228 WP_003899421.1 hypothetical protein -
BJM00_RS14680 3002315..3002704 - 390 WP_003899422.1 hypothetical protein -
BJM00_RS14685 3002610..3002882 + 273 WP_003900544.1 hypothetical protein -
BJM00_RS14690 3002981..3003214 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2993037..3001946 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T67545 WP_003899414.1 NZ_CP017594:c2998037-2997714 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T67545 NZ_CP017594:c2998037-2997714 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT67545 WP_003899415.1 NZ_CP017594:c2998362-2998117 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT67545 NZ_CP017594:c2998362-2998117 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References