Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2983881..2984529 Replicon chromosome
Accession NZ_CP017593
Organism Mycobacterium tuberculosis strain Beijing-like/35049

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BJL99_RS14580 Protein ID WP_003899414.1
Coordinates 2983881..2984204 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BJL99_RS14585 Protein ID WP_003899415.1
Coordinates 2984284..2984529 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJL99_RS14550 2979204..2980202 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BJL99_RS14555 2980216..2980680 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BJL99_RS14560 2980668..2980919 + 252 WP_003908028.1 hypothetical protein -
BJL99_RS14565 2981090..2982529 - 1440 WP_003901443.1 phage major capsid protein -
BJL99_RS14570 2982537..2983070 - 534 WP_003899412.1 HK97 family phage prohead protease -
BJL99_RS14575 2983223..2983714 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BJL99_RS14580 2983881..2984204 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BJL99_RS14585 2984284..2984529 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BJL99_RS14590 2984526..2985953 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BJL99_RS14595 2985955..2986347 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BJL99_RS14600 2986344..2986604 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BJL99_RS14605 2986621..2986983 - 363 WP_003900543.1 hypothetical protein -
BJL99_RS14610 2986986..2988113 - 1128 WP_003899420.1 site-specific integrase -
BJL99_RS14615 2988258..2988485 - 228 WP_003899421.1 hypothetical protein -
BJL99_RS14620 2988482..2988871 - 390 WP_003899422.1 hypothetical protein -
BJL99_RS14625 2988777..2989049 + 273 WP_003900544.1 hypothetical protein -
BJL99_RS14630 2989148..2989381 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2979204..2988113 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T67485 WP_003899414.1 NZ_CP017593:c2984204-2983881 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T67485 NZ_CP017593:c2984204-2983881 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT67485 WP_003899415.1 NZ_CP017593:c2984529-2984284 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT67485 NZ_CP017593:c2984529-2984284 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References