Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1458186..1458822 Replicon chromosome
Accession NZ_CP017484
Organism Mannheimia haemolytica strain 39433

Toxin (Protein)


Gene name higB Uniprot ID A0A378NBU4
Locus tag BG572_RS07265 Protein ID WP_032844503.1
Coordinates 1458186..1458491 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BG572_RS07270 Protein ID WP_032844505.1
Coordinates 1458502..1458822 (+) Length 107 a.a.

Genomic Context

BG572_RS07265BG572_RS07270BG572_RS07275BG572_RS07225BG572_RS13325BG572_RS07240BG572_RS07245BG572_RS07250BG572_RS07255BG572_RS07260BG572_RS07280BG572_RS07285BG572_RS07290BG572_RS07295BG572_RS07300BG572_RS07305BG572_RS07310
Location: 1458186..1458491 (306 bp)
Type: Toxin
Protein ID: WP_032844503.1
Location: 1458502..1458822 (321 bp)
Type: Antitoxin
Protein ID: WP_032844505.1
Location: 1459123..1459653 (531 bp)
Type: Others
Protein ID: WP_032844506.1
Location: 1454441..1454938 (498 bp)
Type: Others
Protein ID: WP_020824116.1
Location: 1455328..1455561 (234 bp)
Type: Others
Protein ID: WP_061887059.1
Location: 1455506..1455856 (351 bp)
Type: Others
Protein ID: WP_006252685.1
Location: 1455857..1456453 (597 bp)
Type: Others
Protein ID: WP_020824120.1
Location: 1456468..1456827 (360 bp)
Type: Others
Protein ID: WP_165876904.1
Location: 1456963..1457436 (474 bp)
Type: Others
Protein ID: WP_006251969.1
Location: 1457426..1457995 (570 bp)
Type: Others
Protein ID: WP_032844502.1
Location: 1459809..1460237 (429 bp)
Type: Others
Protein ID: WP_032844507.1
Location: 1460224..1460436 (213 bp)
Type: Others
Protein ID: WP_006252693.1
Location: 1460527..1461063 (537 bp)
Type: Others
Protein ID: WP_006250086.1
Location: 1461060..1461707 (648 bp)
Type: Others
Protein ID: WP_032844508.1
Location: 1461707..1461991 (285 bp)
Type: Others
Protein ID: WP_032844512.1
Location: 1462052..1462492 (441 bp)
Type: Others
Protein ID: Protein_1411
Location: 1462489..1463328 (840 bp)
Type: Others
Protein ID: WP_006252350.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BG572_RS072251454441..1454938-498WP_020824116.1hypothetical protein-
BG572_RS133251455328..1455561-234WP_061887059.1hypothetical protein-
BG572_RS072401455506..1455856-351WP_006252685.1DUF2570 domain-containing protein-
BG572_RS072451455857..1456453-597WP_020824120.1glycoside hydrolase family 19 protein-
BG572_RS072501456468..1456827-360WP_165876904.1phage holin, lambda family-
BG572_RS072551456963..1457436-474WP_006251969.1hypothetical protein-
BG572_RS072601457426..1457995-570WP_032844502.1recombination protein NinG-
BG572_RS072651458186..1458491+306WP_032844503.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BG572_RS072701458502..1458822+321WP_032844505.1HigA family addiction module antidote proteinAntitoxin
BG572_RS072751459123..1459653+531WP_032844506.1Bro-N domain-containing protein-
BG572_RS072801459809..1460237-429WP_032844507.1recombination protein NinB-
BG572_RS072851460224..1460436-213WP_006252693.1hypothetical protein-
BG572_RS072901460527..1461063-537WP_006250086.1DNA methyltransferase-
BG572_RS072951461060..1461707-648WP_032844508.1bacteriophage replication protein-
BG572_RS073001461707..1461991-285WP_032844512.1hypothetical protein-
BG572_RS073051462052..1462492-441Protein_1411hypothetical protein-
BG572_RS073101462489..1463328-840WP_006252350.1Rha family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1422906..149128568379


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11980.60 Da        Isoelectric Point: 7.1990

>T66911 WP_032844503.1 NZ_CP017484:1458186-1458491 [Mannheimia haemolytica]
MFNLTEAHFRDKALYRFFQYGEVSRTIPANLTSVLARKLDMINAAENLNDLRSPPANRLELLEPKQNNVYSIRVNKQYRL
IFKFENNELSDLYLDPHNYDL

Download         Length: 306 bp

>T66911 NZ_CP017484:1458186-1458491 [Mannheimia haemolytica]
ATGTTTAACTTAACCGAAGCCCATTTTAGAGATAAAGCTCTTTATCGGTTCTTCCAATATGGCGAAGTCAGCAGAACAAT
CCCTGCTAATCTCACAAGCGTATTAGCTCGCAAACTGGATATGATTAATGCAGCTGAAAATCTGAATGACTTACGCAGTC
CGCCTGCTAATCGCTTAGAGTTACTTGAGCCGAAACAAAACAACGTCTATTCAATTCGAGTAAACAAACAGTATCGATTG
ATTTTCAAGTTTGAAAACAATGAACTCTCTGATTTATACCTTGACCCACACAATTACGACCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12123.90 Da        Isoelectric Point: 6.2139

>AT66911 WP_032844505.1 NZ_CP017484:1458502-1458822 [Mannheimia haemolytica]
MMQRKPTPIGEILQEEFLEPLNLKIGDLAEILAVHRNTASNIVNNSCRVSPEMAFKLAKAFDTSPEFWLNLQTACDLWEL
RHNNRFQQSLDSVKAVNHWQGMPAFA

Download         Length: 321 bp

>AT66911 NZ_CP017484:1458502-1458822 [Mannheimia haemolytica]
ATGATGCAACGTAAACCCACCCCTATCGGGGAAATTCTCCAAGAAGAATTTTTAGAGCCACTTAACCTAAAAATTGGCGA
TCTTGCTGAAATCTTAGCTGTTCATCGCAATACCGCCAGCAACATTGTGAATAACAGTTGCCGTGTTAGCCCTGAAATGG
CGTTCAAACTGGCAAAAGCCTTTGATACCAGCCCTGAATTTTGGCTTAACTTACAAACTGCCTGCGATTTATGGGAACTC
CGCCATAACAACCGCTTCCAACAAAGCCTTGATAGCGTAAAAGCCGTAAATCACTGGCAAGGTATGCCTGCATTTGCTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A378NBU4

Antitoxin

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Source
ID
Structure
No matching records found

References