Detailed information of TA system TA066887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2877185..2877845
• Replicon: chromosome
• Accession: NZ_CP017481
• Organism: Pectobacterium polaris strain NIBIO1006

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BJJ97_RS12860
• Protein ID: WP_095994188.1
• Coordinates: 2877185..2877538 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BJJ97_RS12865
• Protein ID: WP_095994189.1
• Coordinates: 2877543..2877845 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJJ97_RS12835	2872349..2872972	-	624	WP_095994184.1	paraquat-inducible protein A	-
BJJ97_RS12840	2872962..2873597	-	636	WP_193438370.1	paraquat-inducible protein A	-
BJJ97_RS12845	2873632..2874294	-	663	WP_095994186.1	DUF3313 domain-containing protein	-
BJJ97_RS12850	2874837..2875805	+	969	WP_095699050.1	chemotaxis protein	-
BJJ97_RS12855	2875921..2876760	-	840	WP_095994187.1	glutathione-dependent disulfide-bond oxidoreductase	-
BJJ97_RS12860	2877185..2877538	+	354	WP_095994188.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJJ97_RS12865	2877543..2877845	+	303	WP_095994189.1	XRE family transcriptional regulator	Antitoxin
BJJ97_RS12870	2877883..2878887	-	1005	WP_095994190.1	threonine/serine dehydratase	-
BJJ97_RS12875	2878940..2879278	+	339	WP_095994191.1	helix-turn-helix domain-containing protein	-
BJJ97_RS12880	2879294..2879686	-	393	WP_095995370.1	helix-turn-helix transcriptional regulator	-
BJJ97_RS12885	2879776..2880201	+	426	WP_095994192.1	DoxX family protein	-
BJJ97_RS12890	2880258..2880893	+	636	WP_095994193.1	NAD(P)H-binding protein	-
BJJ97_RS12895	2880943..2882178	-	1236	WP_095994194.1	MFS transporter	-
BJJ97_RS12900	2882245..2882700	+	456	WP_095995371.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13574.67 Da
• Isoelectric Point: 10.3315

>T66887 WP_095994188.1 NZ_CP017481:2877185-2877538 [Pectobacterium polaris]
VWKIETTDVFDSWFSTLNDRDRAYVLAALIVLREKGPMLSRPYADTVKGSRYSNMKELRIQSRGMPIRAFFAFNPHRTGI
LLCAGNKSGNEKRFYDEMIALADREFTKYLKKSEKKG

Nucleotide

• Length: 354 bp

>T66887 NZ_CP017481:2877185-2877538 [Pectobacterium polaris]
GTGTGGAAAATTGAAACAACGGACGTGTTTGATAGCTGGTTCAGCACATTAAACGATAGGGATCGCGCATATGTGCTTGC
AGCACTTATCGTGTTACGGGAAAAAGGTCCAATGTTATCCAGGCCTTATGCTGATACGGTCAAAGGTTCCCGGTATAGCA
ACATGAAAGAATTGCGTATTCAGAGTCGAGGGATGCCAATACGGGCATTTTTTGCCTTTAACCCACATCGCACGGGGATT
CTCCTCTGTGCGGGGAATAAGTCCGGCAATGAAAAGCGCTTTTATGATGAGATGATCGCGCTTGCTGATCGGGAATTCAC
AAAGTATCTGAAAAAATCAGAGAAGAAGGGGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11151.96 Da
• Isoelectric Point: 6.2269

>AT66887 WP_095994189.1 NZ_CP017481:2877543-2877845 [Pectobacterium polaris]
MGRTLEQLLTDEKPDVVVDAHAIAADMLLNIHLAELRERVQKTQVEMAQVLGLKQPTVAVMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYGFTL

Nucleotide

• Length: 303 bp

>AT66887 NZ_CP017481:2877543-2877845 [Pectobacterium polaris]
ATGGGCAGAACGCTTGAACAGCTTCTTACGGATGAAAAACCAGACGTCGTCGTTGATGCTCACGCTATAGCGGCAGACAT
GTTACTCAATATTCACCTCGCCGAACTGCGTGAGAGGGTGCAAAAAACGCAAGTGGAAATGGCGCAGGTGCTTGGATTAA
AACAGCCGACCGTGGCGGTAATGGAGAAACCCGGTCGCGATCTGAAACTTTCCACACTCAAACGCTATGTTGAGGCGACC
GGCAGTAAACTACGTCTTGATGTTGAACTGCCGGACGGCTCTCACTACGGCTTCACGCTGTAA