Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2616609..2617839 Replicon chromosome
Accession NZ_CP017479
Organism Flavobacterium gilvum strain EM1308

Toxin (Protein)


Gene name HipT Uniprot ID A0A085EFL2
Locus tag EM308_RS10925 Protein ID WP_035640250.1
Coordinates 2616916..2617839 (+) Length 308 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A085EFL3
Locus tag EM308_RS10920 Protein ID WP_035640251.1
Coordinates 2616609..2616923 (+) Length 105 a.a.

Genomic Context

EM308_RS10890EM308_RS10895EM308_RS10905EM308_RS10910EM308_RS10915EM308_RS10920EM308_RS10925EM308_RS10930EM308_RS10900
Location: 2612174..2612446 (273 bp)
Type: Others
Protein ID: WP_197056142.1
Location: 2612524..2613531 (1008 bp)
Type: Others
Protein ID: WP_083273906.1
Location: 2614472..2614843 (372 bp)
Type: Others
Protein ID: WP_197516501.1
Location: 2614854..2615807 (954 bp)
Type: Others
Protein ID: WP_197516509.1
Location: 2616396..2616605 (210 bp)
Type: Others
Protein ID: WP_051877895.1
Location: 2616609..2616923 (315 bp)
Type: Antitoxin
Protein ID: WP_035640251.1
Location: 2616916..2617839 (924 bp)
Type: Toxin
Protein ID: WP_035640250.1
Location: 2618791..2622045 (3255 bp)
Type: Others
Protein ID: WP_051877894.1
Location: 2613802..2614407 (606 bp)
Type: Others
Protein ID: WP_083273907.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EM308_RS108902612174..2612446+273WP_197056142.1GntR family transcriptional regulator-
EM308_RS108952612524..2613531+1008WP_083273906.1family 43 glycosylhydrolase-
EM308_RS109002613802..2614407-606WP_083273907.1Fic family protein-
EM308_RS109052614472..2614843+372WP_197516501.1transposase family protein-
EM308_RS109102614854..2615807+954WP_197516509.1transposase-
EM308_RS109152616396..2616605+210WP_051877895.1helix-turn-helix transcriptional regulator-
EM308_RS109202616609..2616923+315WP_035640251.1HipA N-terminal domain-containing proteinAntitoxin
EM308_RS109252616916..2617839+924WP_035640250.1HipA domain-containing proteinToxin
EM308_RS109302618791..2622045+3255WP_051877894.1T9SS type B sorting domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(52-278)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35380.60 Da        Isoelectric Point: 8.4073

>T66873 WP_035640250.1 NZ_CP017479:2616916-2617839 [Flavobacterium gilvum]
MNRCPITYQPCGEDLYSSEGLKLLSPKLTSFENLPFSASEQRQEAANRATRLSIQGVQPKLSAILSVKNQQFEIVDQFGN
FIIKPQSDIFPELPENEDLTMRMAKVYGIDVPFHGLVYSKDNSKSYFIKRFDRYGKGKKYATEDFAQLTGSSRDTKYNFT
MEKIVKVIDDFCTFPSIEKAEFFKRTLFCFITGNEDMHLKNFSLITKSGKTTLTPVYDFLNSSIAIKNPQEEMALSLKGK
KSNFKAGDLIDYFGKERLGLSDKVIDQTLKKMFENVEKWNELIEISFLSDEMKEKYLRLLSERLGRF

Download         Length: 924 bp

>T66873 NZ_CP017479:2616916-2617839 [Flavobacterium gilvum]
ATGAATAGATGTCCTATTACTTACCAACCTTGTGGGGAAGATTTATACAGCAGCGAGGGATTGAAGCTACTGTCTCCCAA
ATTGACATCTTTTGAAAATCTTCCTTTTTCAGCTTCAGAGCAGCGGCAAGAAGCGGCTAATAGAGCGACTAGATTATCTA
TTCAGGGCGTTCAGCCTAAGTTAAGTGCTATCTTGTCTGTTAAAAACCAGCAATTTGAAATCGTAGATCAGTTTGGGAAT
TTTATAATCAAACCCCAAAGTGACATATTTCCGGAATTGCCCGAGAATGAAGATCTGACCATGCGCATGGCAAAAGTTTA
CGGTATCGATGTTCCGTTTCATGGGCTGGTTTATTCCAAAGACAATTCTAAATCCTATTTTATAAAAAGGTTTGACCGAT
ACGGGAAAGGAAAAAAATATGCTACGGAAGATTTTGCGCAGCTAACAGGAAGCTCAAGGGATACCAAATATAATTTTACA
ATGGAAAAGATTGTAAAGGTTATTGATGATTTCTGTACATTTCCCTCAATCGAGAAAGCGGAATTTTTTAAGAGAACATT
ATTCTGCTTTATCACAGGCAACGAAGACATGCACCTGAAAAACTTTTCTTTGATAACAAAATCTGGAAAAACGACCTTAA
CACCTGTTTATGATTTTCTGAATTCTTCGATTGCAATAAAAAATCCTCAGGAAGAAATGGCTTTATCATTAAAAGGAAAG
AAAAGTAATTTCAAAGCAGGTGATTTGATTGATTATTTTGGGAAAGAAAGGTTAGGGTTAAGTGATAAAGTTATCGATCA
GACATTAAAAAAAATGTTTGAAAATGTTGAAAAATGGAACGAGTTAATCGAAATTTCTTTTTTATCCGATGAGATGAAAG
AAAAGTATCTAAGGCTTTTGTCAGAGCGATTGGGAAGATTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11680.34 Da        Isoelectric Point: 4.3992

>AT66873 WP_035640251.1 NZ_CP017479:2616609-2616923 [Flavobacterium gilvum]
MRKAVIYVHDVRAGELMEEENGGYVFAYDEEYSLEPVSLTMPVTQRNYSFLTFPPFFEGLLPEGIMLEGLLKINKIDKKD
YFSQLVAAGNDLVGAVTVKASSHE

Download         Length: 315 bp

>AT66873 NZ_CP017479:2616609-2616923 [Flavobacterium gilvum]
ATGAGAAAAGCAGTTATTTATGTCCATGATGTCAGGGCAGGGGAGCTCATGGAGGAAGAAAACGGAGGATATGTATTTGC
ATATGATGAAGAATATTCTTTGGAACCTGTTTCGCTTACTATGCCCGTTACCCAAAGAAATTATTCTTTTTTGACTTTTC
CTCCATTTTTTGAAGGACTGCTCCCGGAAGGAATAATGTTGGAGGGGCTTTTAAAGATAAATAAGATAGATAAGAAAGAT
TACTTTTCGCAGCTTGTTGCCGCAGGAAATGATTTAGTGGGAGCTGTAACGGTTAAAGCTTCAAGTCATGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A085EFL2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A085EFL3

References