66873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2616609..2617839 Replicon chromosome
Accession NZ_CP017479
Organism Flavobacterium gilvum strain EM1308

Toxin (Protein)


Gene name HipT Uniprot ID A0A085EFL2
Locus tag EM308_RS10925 Protein ID WP_035640250.1
Coordinates 2616916..2617839 (+) Length 308 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A085EFL3
Locus tag EM308_RS10920 Protein ID WP_035640251.1
Coordinates 2616609..2616923 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM308_RS10890 2612174..2612446 + 273 WP_197056142.1 GntR family transcriptional regulator -
EM308_RS10895 2612524..2613531 + 1008 WP_083273906.1 family 43 glycosylhydrolase -
EM308_RS10900 2613802..2614407 - 606 WP_083273907.1 Fic family protein -
EM308_RS10905 2614472..2614843 + 372 WP_197516501.1 transposase family protein -
EM308_RS10910 2614854..2615807 + 954 WP_197516509.1 transposase -
EM308_RS10915 2616396..2616605 + 210 WP_051877895.1 helix-turn-helix transcriptional regulator -
EM308_RS10920 2616609..2616923 + 315 WP_035640251.1 HipA N-terminal domain-containing protein Antitoxin
EM308_RS10925 2616916..2617839 + 924 WP_035640250.1 HipA domain-containing protein Toxin
EM308_RS10930 2618791..2622045 + 3255 WP_051877894.1 T9SS type B sorting domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(52-278)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35380.60 Da        Isoelectric Point: 8.4073

>T66873 WP_035640250.1 NZ_CP017479:2616916-2617839 [Flavobacterium gilvum]
MNRCPITYQPCGEDLYSSEGLKLLSPKLTSFENLPFSASEQRQEAANRATRLSIQGVQPKLSAILSVKNQQFEIVDQFGN
FIIKPQSDIFPELPENEDLTMRMAKVYGIDVPFHGLVYSKDNSKSYFIKRFDRYGKGKKYATEDFAQLTGSSRDTKYNFT
MEKIVKVIDDFCTFPSIEKAEFFKRTLFCFITGNEDMHLKNFSLITKSGKTTLTPVYDFLNSSIAIKNPQEEMALSLKGK
KSNFKAGDLIDYFGKERLGLSDKVIDQTLKKMFENVEKWNELIEISFLSDEMKEKYLRLLSERLGRF

Download         Length: 924 bp

>T66873 NZ_CP017479:2616916-2617839 [Flavobacterium gilvum]
ATGAATAGATGTCCTATTACTTACCAACCTTGTGGGGAAGATTTATACAGCAGCGAGGGATTGAAGCTACTGTCTCCCAA
ATTGACATCTTTTGAAAATCTTCCTTTTTCAGCTTCAGAGCAGCGGCAAGAAGCGGCTAATAGAGCGACTAGATTATCTA
TTCAGGGCGTTCAGCCTAAGTTAAGTGCTATCTTGTCTGTTAAAAACCAGCAATTTGAAATCGTAGATCAGTTTGGGAAT
TTTATAATCAAACCCCAAAGTGACATATTTCCGGAATTGCCCGAGAATGAAGATCTGACCATGCGCATGGCAAAAGTTTA
CGGTATCGATGTTCCGTTTCATGGGCTGGTTTATTCCAAAGACAATTCTAAATCCTATTTTATAAAAAGGTTTGACCGAT
ACGGGAAAGGAAAAAAATATGCTACGGAAGATTTTGCGCAGCTAACAGGAAGCTCAAGGGATACCAAATATAATTTTACA
ATGGAAAAGATTGTAAAGGTTATTGATGATTTCTGTACATTTCCCTCAATCGAGAAAGCGGAATTTTTTAAGAGAACATT
ATTCTGCTTTATCACAGGCAACGAAGACATGCACCTGAAAAACTTTTCTTTGATAACAAAATCTGGAAAAACGACCTTAA
CACCTGTTTATGATTTTCTGAATTCTTCGATTGCAATAAAAAATCCTCAGGAAGAAATGGCTTTATCATTAAAAGGAAAG
AAAAGTAATTTCAAAGCAGGTGATTTGATTGATTATTTTGGGAAAGAAAGGTTAGGGTTAAGTGATAAAGTTATCGATCA
GACATTAAAAAAAATGTTTGAAAATGTTGAAAAATGGAACGAGTTAATCGAAATTTCTTTTTTATCCGATGAGATGAAAG
AAAAGTATCTAAGGCTTTTGTCAGAGCGATTGGGAAGATTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11680.34 Da        Isoelectric Point: 4.3992

>AT66873 WP_035640251.1 NZ_CP017479:2616609-2616923 [Flavobacterium gilvum]
MRKAVIYVHDVRAGELMEEENGGYVFAYDEEYSLEPVSLTMPVTQRNYSFLTFPPFFEGLLPEGIMLEGLLKINKIDKKD
YFSQLVAAGNDLVGAVTVKASSHE

Download         Length: 315 bp

>AT66873 NZ_CP017479:2616609-2616923 [Flavobacterium gilvum]
ATGAGAAAAGCAGTTATTTATGTCCATGATGTCAGGGCAGGGGAGCTCATGGAGGAAGAAAACGGAGGATATGTATTTGC
ATATGATGAAGAATATTCTTTGGAACCTGTTTCGCTTACTATGCCCGTTACCCAAAGAAATTATTCTTTTTTGACTTTTC
CTCCATTTTTTGAAGGACTGCTCCCGGAAGGAATAATGTTGGAGGGGCTTTTAAAGATAAATAAGATAGATAAGAAAGAT
TACTTTTCGCAGCTTGTTGCCGCAGGAAATGATTTAGTGGGAGCTGTAACGGTTAAAGCTTCAAGTCATGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085EFL2

Antitoxin

Source ID Structure
AlphaFold DB A0A085EFL3

References