66825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2705319..2706562 Replicon chromosome
Accession NZ_CP017457
Organism Legionella pneumophila subsp. fraseri strain Detroit-1

Toxin (Protein)


Gene name HipT Uniprot ID A0A2S6EXA8
Locus tag BIZ52_RS12075 Protein ID WP_027227417.1
Coordinates 2705624..2706562 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S6EX97
Locus tag BIZ52_RS12070 Protein ID WP_027227416.1
Coordinates 2705319..2705627 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BIZ52_RS12035 2700668..2701528 + 861 WP_027227410.1 DUF2608 domain-containing protein -
BIZ52_RS12040 2701880..2702144 - 265 Protein_2339 hypothetical protein -
BIZ52_RS12045 2702192..2702503 - 312 WP_027227411.1 cupin -
BIZ52_RS12050 2702519..2702767 - 249 WP_031301595.1 hypothetical protein -
BIZ52_RS12055 2703074..2703547 + 474 WP_027227413.1 hypothetical protein -
BIZ52_RS12060 2703737..2704654 + 918 WP_027227414.1 LysR family transcriptional regulator -
BIZ52_RS12065 2705095..2705322 + 228 WP_027227415.1 helix-turn-helix transcriptional regulator -
BIZ52_RS12070 2705319..2705627 + 309 WP_027227416.1 HipA N-terminal domain-containing protein Antitoxin
BIZ52_RS12075 2705624..2706562 + 939 WP_027227417.1 lpg2370 family Dot/Icm T4SS effector Toxin
BIZ52_RS12080 2706856..2708019 + 1164 WP_027227418.1 hypothetical protein -
BIZ52_RS12085 2708011..2709198 - 1188 WP_027227419.1 fatty acid desaturase -
BIZ52_RS12090 2709323..2709490 - 168 WP_011214444.1 DUF3309 domain-containing protein -
BIZ52_RS12095 2710089..2710445 + 357 WP_063720028.1 hypothetical protein -
BIZ52_RS12100 2710486..2710770 - 285 Protein_2351 hypothetical protein -
BIZ52_RS12105 2710814..2711455 - 642 WP_027227422.1 RsmD family RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36142.94 Da        Isoelectric Point: 9.5859

>T66825 WP_027227417.1 NZ_CP017457:2705624-2706562 [Legionella pneumophila subsp. fraseri]
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD

Download         Length: 939 bp

>T66825 NZ_CP017457:2705624-2706562 [Legionella pneumophila subsp. fraseri]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11611.39 Da        Isoelectric Point: 4.5556

>AT66825 WP_027227416.1 NZ_CP017457:2705319-2705627 [Legionella pneumophila subsp. fraseri]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT66825 NZ_CP017457:2705319-2705627 [Legionella pneumophila subsp. fraseri]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6EXA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6EX97

References