66758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4720273..4720685 Replicon chromosome
Accession NZ_CP017446
Organism Escherichia coli O157:H7 strain 9234

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag A4C47_RS24295 Protein ID WP_000132630.1
Coordinates 4720344..4720685 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4720273..4720349 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C47_RS24285 4716900..4718369 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
A4C47_RS24290 4718369..4720123 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4720273..4720349 - 77 NuclAT_14 - Antitoxin
- 4720273..4720349 - 77 NuclAT_14 - Antitoxin
- 4720273..4720349 - 77 NuclAT_14 - Antitoxin
- 4720273..4720349 - 77 NuclAT_14 - Antitoxin
- 4720273..4720349 - 77 NuclAT_15 - Antitoxin
- 4720273..4720349 - 77 NuclAT_15 - Antitoxin
- 4720273..4720349 - 77 NuclAT_15 - Antitoxin
- 4720273..4720349 - 77 NuclAT_15 - Antitoxin
A4C47_RS24295 4720344..4720685 + 342 WP_000132630.1 endoribonuclease SymE Toxin
A4C47_RS30215 4720732..4721895 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
A4C47_RS24305 4721943..4722824 - 882 WP_001304007.1 DUF262 domain-containing protein -
A4C47_RS24310 4722921..4723085 - 165 WP_000394274.1 DUF1127 domain-containing protein -
A4C47_RS24315 4723262..4724674 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
A4C47_RS31690 4724917..4725117 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4712472..4733681 21209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T66758 WP_000132630.1 NZ_CP017446:4720344-4720685 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T66758 NZ_CP017446:4720344-4720685 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT66758 NZ_CP017446:c4720349-4720273 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References