Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3487235..3487460 Replicon chromosome
Accession NZ_CP017446
Organism Escherichia coli O157:H7 strain 9234

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag A4C47_RS18390 Protein ID WP_000813263.1
Coordinates 3487235..3487390 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 3487402..3487460 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C47_RS18355 3482689..3483402 - 714 WP_000261909.1 helix-turn-helix domain-containing protein -
A4C47_RS18360 3483540..3483736 - 197 Protein_3470 TrmB family transcriptional regulator -
A4C47_RS18365 3484023..3484841 - 819 WP_000265269.1 CPBP family intramembrane metalloprotease -
A4C47_RS18370 3484993..3485364 - 372 WP_000090264.1 antitermination protein -
A4C47_RS18375 3485354..3485725 - 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
A4C47_RS18380 3485738..3486787 - 1050 WP_001265172.1 DUF968 domain-containing protein -
A4C47_RS29760 3486789..3487067 - 279 WP_001341388.1 hypothetical protein -
A4C47_RS18390 3487235..3487390 - 156 WP_000813263.1 type I toxin-antitoxin system toxin HokD Toxin
- 3487402..3487460 + 59 - - Antitoxin
A4C47_RS18405 3489308..3490081 + 774 WP_000160654.1 alpha/beta hydrolase -
A4C47_RS18410 3490433..3490846 - 414 WP_001151233.1 DUF977 family protein -
A4C47_RS18415 3490862..3491632 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A4C47_RS18420 3491654..3492400 - 747 WP_000788751.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5722.86 Da        Isoelectric Point: 6.1531

>T66750 WP_000813263.1 NZ_CP017446:c3487390-3487235 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T66750 NZ_CP017446:c3487390-3487235 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT66750 NZ_CP017446:3487402-3487460 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References