Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4413886..4414425 Replicon chromosome
Accession NZ_CP017440
Organism Escherichia coli O157:H7 strain 3384

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag A4C38_RS22930 Protein ID WP_001303998.1
Coordinates 4414165..4414425 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag A4C38_RS22925 Protein ID WP_000729705.1
Coordinates 4413886..4414146 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C38_RS22905 4409640..4410425 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
A4C38_RS22910 4410397..4412109 + 1713 Protein_4354 flagellar biosynthesis protein FlhA -
A4C38_RS31585 4412254..4412751 - 498 Protein_4355 REP-associated tyrosine transposase RayT -
A4C38_RS22920 4412927..4413700 - 774 WP_000543891.1 C40 family peptidase -
A4C38_RS22925 4413886..4414146 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
A4C38_RS22930 4414165..4414425 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
A4C38_RS22935 4414581..4415321 + 741 WP_001225679.1 murein L,D-transpeptidase -
A4C38_RS22940 4415292..4416059 - 768 WP_001301698.1 class II glutamine amidotransferase -
A4C38_RS22945 4416164..4416742 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T66653 WP_001303998.1 NZ_CP017440:4414165-4414425 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T66653 NZ_CP017440:4414165-4414425 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT66653 WP_000729705.1 NZ_CP017440:4413886-4414146 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT66653 NZ_CP017440:4413886-4414146 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References