Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4726310..4726722 | Replicon | chromosome |
Accession | NZ_CP017438 | ||
Organism | Escherichia coli O157:H7 strain 2159 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | A4C45_RS24340 | Protein ID | WP_000132630.1 |
Coordinates | 4726381..4726722 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4726310..4726386 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A4C45_RS24330 | 4722937..4724406 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
A4C45_RS24335 | 4724406..4726160 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- | 4726310..4726386 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4726310..4726386 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4726310..4726386 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4726310..4726386 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4726310..4726386 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4726310..4726386 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4726310..4726386 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4726310..4726386 | - | 77 | NuclAT_15 | - | Antitoxin |
A4C45_RS24340 | 4726381..4726722 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
A4C45_RS30260 | 4726769..4727932 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
A4C45_RS24350 | 4727980..4728861 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
A4C45_RS24355 | 4728958..4729122 | - | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
A4C45_RS24360 | 4729299..4730711 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
A4C45_RS31770 | 4730954..4731154 | - | 201 | WP_001310455.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4718509..4739718 | 21209 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T66624 WP_000132630.1 NZ_CP017438:4726381-4726722 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T66624 NZ_CP017438:4726381-4726722 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT66624 NZ_CP017438:c4726386-4726310 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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