Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4726310..4726722 Replicon chromosome
Accession NZ_CP017438
Organism Escherichia coli O157:H7 strain 2159

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag A4C45_RS24340 Protein ID WP_000132630.1
Coordinates 4726381..4726722 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4726310..4726386 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C45_RS24330 4722937..4724406 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
A4C45_RS24335 4724406..4726160 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4726310..4726386 - 77 NuclAT_14 - Antitoxin
- 4726310..4726386 - 77 NuclAT_14 - Antitoxin
- 4726310..4726386 - 77 NuclAT_14 - Antitoxin
- 4726310..4726386 - 77 NuclAT_14 - Antitoxin
- 4726310..4726386 - 77 NuclAT_15 - Antitoxin
- 4726310..4726386 - 77 NuclAT_15 - Antitoxin
- 4726310..4726386 - 77 NuclAT_15 - Antitoxin
- 4726310..4726386 - 77 NuclAT_15 - Antitoxin
A4C45_RS24340 4726381..4726722 + 342 WP_000132630.1 endoribonuclease SymE Toxin
A4C45_RS30260 4726769..4727932 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
A4C45_RS24350 4727980..4728861 - 882 WP_001304007.1 DUF262 domain-containing protein -
A4C45_RS24355 4728958..4729122 - 165 WP_000394274.1 DUF1127 domain-containing protein -
A4C45_RS24360 4729299..4730711 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
A4C45_RS31770 4730954..4731154 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4718509..4739718 21209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T66624 WP_000132630.1 NZ_CP017438:4726381-4726722 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T66624 NZ_CP017438:4726381-4726722 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT66624 NZ_CP017438:c4726386-4726310 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References