Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 3491760..3491985 Replicon chromosome
Accession NZ_CP017436
Organism Escherichia coli O157:H7 strain 2149

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag A4C44_RS18415 Protein ID WP_000813263.1
Coordinates 3491760..3491915 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 3491927..3491985 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4C44_RS18380 3487214..3487927 - 714 WP_000261909.1 helix-turn-helix domain-containing protein -
A4C44_RS18385 3488065..3488261 - 197 Protein_3472 TrmB family transcriptional regulator -
A4C44_RS18390 3488548..3489366 - 819 WP_000265269.1 CPBP family intramembrane metalloprotease -
A4C44_RS18395 3489518..3489889 - 372 WP_000090264.1 antitermination protein -
A4C44_RS18400 3489879..3490250 - 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
A4C44_RS18405 3490263..3491312 - 1050 WP_001265172.1 DUF968 domain-containing protein -
A4C44_RS29730 3491314..3491592 - 279 WP_001341388.1 hypothetical protein -
A4C44_RS18415 3491760..3491915 - 156 WP_000813263.1 type I toxin-antitoxin system toxin HokD Toxin
- 3491927..3491985 + 59 - - Antitoxin
A4C44_RS18420 3492520..3493293 + 774 WP_000160654.1 alpha/beta hydrolase -
A4C44_RS18425 3493645..3494058 - 414 WP_001151233.1 DUF977 family protein -
A4C44_RS18430 3494074..3494844 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A4C44_RS18435 3494866..3495612 - 747 WP_000788751.1 ATP-binding protein -
A4C44_RS18440 3495619..3496710 - 1092 WP_001205823.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 52 a.a.        Molecular weight: 5722.86 Da        Isoelectric Point: 6.1531

>T66580 WP_000813263.1 NZ_CP017436:c3491915-3491760 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T66580 NZ_CP017436:c3491915-3491760 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT66580 NZ_CP017436:3491927-3491985 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References