Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 52919..53442 Replicon plasmid unnamed4
Accession NZ_CP017431
Organism Staphylococcus simulans strain MR4

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag BI283_RS13180 Protein ID WP_106421233.1
Coordinates 52919..53185 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag BI283_RS13185 Protein ID WP_106421232.1
Coordinates 53185..53442 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI283_RS14055 48459..48602 + 144 WP_106421236.1 Rep protein -
BI283_RS13165 49699..50244 + 546 WP_105988897.1 hypothetical protein -
BI283_RS13170 50783..51628 + 846 WP_106421234.1 protein rep -
BI283_RS13175 51638..52312 - 675 WP_103370613.1 IS6 family transposase -
BI283_RS13180 52919..53185 - 267 WP_106421233.1 Txe/YoeB family addiction module toxin Toxin
BI283_RS13185 53185..53442 - 258 WP_106421232.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BI283_RS13195 54359..54841 - 483 Protein_62 recombinase family protein -
BI283_RS13200 55909..56160 + 252 WP_106421230.1 autorepressor SdpR family transcription factor -
BI283_RS13205 56179..56820 + 642 WP_106421229.1 SdpI family protein -
BI283_RS13210 56861..57247 - 387 WP_106421228.1 DUF393 domain-containing protein -
BI283_RS13215 57250..57855 - 606 WP_106421227.1 sporulation delaying protein family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid lnu(A) - 1..147416 147416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10642.14 Da        Isoelectric Point: 10.0751

>T66522 WP_106421233.1 NZ_CP017431:c53185-52919 [Staphylococcus simulans]
MSNYSISIKNSAKSDLKKIQQSQLKSHFLKIVEILKIDPYYPNQSFEKLQPKHLGRYSRRINHQHRVVYTVDEERKEVYI
FSAWSHYE

Download         Length: 267 bp

>T66522 NZ_CP017431:c53185-52919 [Staphylococcus simulans]
ATGAGTAACTACAGTATTTCAATTAAAAATTCGGCGAAAAGTGATTTAAAAAAAATACAGCAGTCACAACTTAAAAGTCA
TTTTTTAAAAATTGTAGAAATATTAAAGATAGACCCATATTATCCAAACCAATCATTTGAAAAGTTACAACCAAAACATT
TAGGGCGCTATTCAAGGCGTATCAATCATCAGCATAGAGTAGTTTATACAGTCGATGAAGAAAGAAAAGAAGTATATATT
TTTTCTGCGTGGTCTCATTATGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9832.82 Da        Isoelectric Point: 4.3646

>AT66522 WP_106421232.1 NZ_CP017431:c53442-53185 [Staphylococcus simulans]
MNIKTPTNARKEFYELLKQVNNNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVREREKDDSGYTNIDDL
DWDNL

Download         Length: 258 bp

>AT66522 NZ_CP017431:c53442-53185 [Staphylococcus simulans]
ATGAATATTAAAACTCCTACAAATGCGAGAAAAGAGTTTTACGAGCTGTTAAAACAAGTTAATAATAATCATGAGCCTGT
AATTATAAGTGGCTCTAAAAGTGAAAATAACGCAGTTATTGTAAGTCAAAAAGATTGGAATAGTATTCAAGAAACGTTGT
TTCTTGAATCAACTGGCACTATGGATAAAGTAAGAGAACGTGAAAAAGATGATAGTGGTTATACAAATATTGATGATTTA
GATTGGGATAACTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References