Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 94298..94821 Replicon plasmid unnamed5
Accession NZ_CP017429
Organism Staphylococcus simulans strain MR3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag BI282_RS13485 Protein ID WP_106421233.1
Coordinates 94555..94821 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag BI282_RS13480 Protein ID WP_106421232.1
Coordinates 94298..94555 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI282_RS13450 89885..90490 + 606 WP_106421227.1 sporulation delaying protein family toxin -
BI282_RS13455 90493..90879 + 387 WP_106421228.1 DUF393 domain-containing protein -
BI282_RS13460 90920..91561 - 642 WP_106421229.1 SdpI family protein -
BI282_RS13465 91580..91831 - 252 WP_106421230.1 autorepressor SdpR family transcription factor -
BI282_RS13470 92899..93381 + 483 Protein_124 recombinase family protein -
BI282_RS13480 94298..94555 + 258 WP_106421232.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BI282_RS13485 94555..94821 + 267 WP_106421233.1 Txe/YoeB family addiction module toxin Toxin
BI282_RS13490 95428..96102 + 675 WP_103370613.1 IS6 family transposase -
BI282_RS13495 96112..96957 - 846 WP_106421234.1 protein rep -
BI282_RS13500 97496..98041 - 546 WP_105988897.1 hypothetical protein -
BI282_RS14030 99138..99281 - 144 WP_106421236.1 Rep protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid lnu(A) - 1..146786 146786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10642.14 Da        Isoelectric Point: 10.0751

>T66518 WP_106421233.1 NZ_CP017429:94555-94821 [Staphylococcus simulans]
MSNYSISIKNSAKSDLKKIQQSQLKSHFLKIVEILKIDPYYPNQSFEKLQPKHLGRYSRRINHQHRVVYTVDEERKEVYI
FSAWSHYE

Download         Length: 267 bp

>T66518 NZ_CP017429:94555-94821 [Staphylococcus simulans]
ATGAGTAACTACAGTATTTCAATTAAAAATTCGGCGAAAAGTGATTTAAAAAAAATACAGCAGTCACAACTTAAAAGTCA
TTTTTTAAAAATTGTAGAAATATTAAAGATAGACCCATATTATCCAAACCAATCATTTGAAAAGTTACAACCAAAACATT
TAGGGCGCTATTCAAGGCGTATCAATCATCAGCATAGAGTAGTTTATACAGTCGATGAAGAAAGAAAAGAAGTATATATT
TTTTCTGCGTGGTCTCATTATGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9832.82 Da        Isoelectric Point: 4.3646

>AT66518 WP_106421232.1 NZ_CP017429:94298-94555 [Staphylococcus simulans]
MNIKTPTNARKEFYELLKQVNNNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVREREKDDSGYTNIDDL
DWDNL

Download         Length: 258 bp

>AT66518 NZ_CP017429:94298-94555 [Staphylococcus simulans]
ATGAATATTAAAACTCCTACAAATGCGAGAAAAGAGTTTTACGAGCTGTTAAAACAAGTTAATAATAATCATGAGCCTGT
AATTATAAGTGGCTCTAAAAGTGAAAATAACGCAGTTATTGTAAGTCAAAAAGATTGGAATAGTATTCAAGAAACGTTGT
TTCTTGAATCAACTGGCACTATGGATAAAGTAAGAGAACGTGAAAAAGATGATAGTGGTTATACAAATATTGATGATTTA
GATTGGGATAACTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References