Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5642016..5642833 Replicon chromosome
Accession NZ_CP017420
Organism Delftia tsuruhatensis strain CM13

Toxin (Protein)


Gene name yhaV Uniprot ID A0A1D8J768
Locus tag BI380_RS25895 Protein ID WP_046241156.1
Coordinates 5642016..5642507 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A031I1Z5
Locus tag BI380_RS25900 Protein ID WP_016452695.1
Coordinates 5642504..5642833 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI380_RS25865 5637118..5637615 + 498 WP_070081031.1 cobalamin biosynthesis protein -
BI380_RS25870 5637612..5638502 + 891 WP_070080856.1 precorrin-4 C(11)-methyltransferase -
BI380_RS25875 5638499..5639296 + 798 WP_043790971.1 precorrin-6A synthase (deacetylating) -
BI380_RS25880 5639360..5639689 + 330 WP_043790973.1 DHCW motif cupin fold protein -
BI380_RS25885 5639965..5641374 + 1410 WP_046988679.1 chloride channel protein -
BI380_RS25890 5641489..5642001 + 513 WP_016448386.1 MgtC/SapB family protein -
BI380_RS25895 5642016..5642507 - 492 WP_046241156.1 type II toxin-antitoxin system YhaV family toxin Toxin
BI380_RS25900 5642504..5642833 - 330 WP_016452695.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
BI380_RS25905 5642931..5645174 - 2244 WP_046241157.1 TonB-dependent receptor -
BI380_RS25910 5645298..5645702 - 405 WP_046241158.1 hypothetical protein -
BI380_RS25915 5645731..5646393 - 663 WP_046241159.1 pyridoxamine 5'-phosphate oxidase family protein -
BI380_RS25920 5646464..5647297 + 834 WP_070080857.1 helix-turn-helix transcriptional regulator -
BI380_RS25925 5647364..5647639 + 276 WP_016448378.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18800.39 Da        Isoelectric Point: 10.2528

>T66513 WP_046241156.1 NZ_CP017420:c5642507-5642016 [Delftia tsuruhatensis]
MSAVPPAPLRIHGWTVFMHPLFLAQLQALSHEVEGLKTKDPGGYTRKNATKRLAAIRKLAFDVIPQDPTRPDYRQGHTLG
EEHKHWFRARFFQQYRLFFRFHAPSKIIVFAWVNDEDTRRAYEGSDDAYRVFRKMLANGHPPGDWDSLLAQAKSPPPDSQ
PHA

Download         Length: 492 bp

>T66513 NZ_CP017420:c5642507-5642016 [Delftia tsuruhatensis]
ATGAGCGCCGTACCGCCCGCCCCCTTGCGCATCCACGGCTGGACGGTATTCATGCACCCGCTTTTCCTGGCCCAGCTACA
GGCGTTGAGCCACGAAGTGGAGGGTCTGAAAACGAAGGACCCTGGCGGGTACACACGCAAGAACGCGACCAAGCGATTGG
CGGCGATCCGCAAGCTGGCATTCGATGTCATCCCGCAGGATCCGACGCGGCCAGACTACCGCCAGGGCCATACCCTGGGC
GAGGAGCACAAGCACTGGTTTCGGGCCAGGTTCTTCCAGCAGTACCGCCTGTTCTTTCGCTTTCACGCCCCCAGCAAAAT
CATCGTGTTCGCCTGGGTCAACGATGAGGACACCAGGCGAGCCTATGAGGGCAGCGACGATGCCTACAGGGTGTTCCGAA
AAATGCTCGCCAACGGGCACCCTCCTGGCGATTGGGACAGTTTGCTGGCACAGGCGAAGTCCCCGCCACCCGACTCACAG
CCGCACGCCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12036.45 Da        Isoelectric Point: 4.1858

>AT66513 WP_016452695.1 NZ_CP017420:c5642833-5642504 [Delftia tsuruhatensis]
MFSTLEAESTLTDRYQTTIPEAVRRALHLSKRDRIHYTILPGGEVVLSRADSAEDADPVLGQFLGFLAQDMAAHPERLQT
MDARLAQQIQALTEGIEVDLDAPLSADDE

Download         Length: 330 bp

>AT66513 NZ_CP017420:c5642833-5642504 [Delftia tsuruhatensis]
ATGTTTTCGACACTTGAAGCCGAATCCACGCTCACTGACCGCTACCAGACCACCATTCCCGAAGCCGTTCGCCGCGCATT
GCACCTGAGCAAGCGCGACAGGATCCACTACACCATCCTGCCCGGCGGGGAGGTCGTGCTCAGTCGCGCCGACTCCGCCG
AGGATGCCGATCCCGTGCTGGGCCAGTTTCTCGGCTTTCTGGCCCAGGACATGGCAGCCCACCCCGAGCGCCTGCAGACC
ATGGATGCCCGTCTGGCGCAGCAGATCCAGGCGCTGACCGAAGGCATCGAGGTCGATCTGGATGCACCGCTTTCGGCAGA
CGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8J768

Antitoxin

Source ID Structure
AlphaFold DB A0A031I1Z5

References