Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3984850..3985524 Replicon chromosome
Accession NZ_CP017420
Organism Delftia tsuruhatensis strain CM13

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BI380_RS18540 Protein ID WP_043789322.1
Coordinates 3984850..3985131 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag BI380_RS18545 Protein ID WP_012203141.1
Coordinates 3985213..3985524 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI380_RS18520 3980516..3981082 - 567 WP_043789355.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
BI380_RS18525 3981088..3982116 - 1029 WP_016451881.1 type I-F CRISPR-associated protein Csy3 -
BI380_RS18530 3982171..3983289 - 1119 WP_046240414.1 type I-F CRISPR-associated protein Csy2 -
BI380_RS18535 3983286..3984683 - 1398 WP_046240415.1 type I-F CRISPR-associated protein Csy1 -
BI380_RS18540 3984850..3985131 + 282 WP_043789322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BI380_RS18545 3985213..3985524 + 312 WP_012203141.1 HigA family addiction module antidote protein Antitoxin
BI380_RS18550 3985528..3989016 - 3489 WP_046240416.1 type I-F CRISPR-associated helicase Cas3 -
BI380_RS18555 3989013..3990035 - 1023 WP_046240417.1 type I-F CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10721.30 Da        Isoelectric Point: 8.5442

>T66509 WP_043789322.1 NZ_CP017420:3984850-3985131 [Delftia tsuruhatensis]
MAITSFKCPETQRLFTSGKTRRFANIQSVAERKLAQLDAAVTLEFLRSPPGNRLEMLVGDRQGQHSIRINDQWRLCFVWT
EKGVVDVEIVDYH

Download         Length: 282 bp

>T66509 NZ_CP017420:3984850-3985131 [Delftia tsuruhatensis]
ATGGCGATCACTTCCTTCAAGTGCCCGGAAACACAGCGCCTGTTCACCAGCGGCAAGACCCGCCGCTTCGCCAACATCCA
GAGCGTGGCGGAGCGCAAGCTGGCTCAGCTGGATGCGGCTGTGACACTTGAATTTCTGCGCAGCCCTCCTGGCAATCGCC
TGGAAATGCTCGTGGGAGATCGGCAGGGCCAGCACAGCATCCGCATCAACGACCAGTGGCGCCTCTGCTTTGTCTGGACG
GAAAAGGGAGTGGTTGACGTAGAGATAGTGGATTACCACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11615.32 Da        Isoelectric Point: 8.6927

>AT66509 WP_012203141.1 NZ_CP017420:3985213-3985524 [Delftia tsuruhatensis]
MLKNGMRPIHPGEVLREDYLKPMDMSANALARHLHVPASRVNDIVLERRGITADTALRLSRFFGGDAQSWLNLQTAYDLR
TAELNAELQASVRQVHPMQLHTA

Download         Length: 312 bp

>AT66509 NZ_CP017420:3985213-3985524 [Delftia tsuruhatensis]
ATGCTTAAAAACGGCATGCGCCCCATACACCCAGGTGAAGTCCTGCGCGAGGACTACCTGAAGCCCATGGACATGAGCGC
CAACGCGCTGGCCAGGCACCTGCACGTTCCCGCCTCGCGCGTGAACGACATCGTGCTGGAGCGGCGCGGCATCACGGCCG
ACACGGCGCTGCGGCTGAGCCGCTTTTTTGGGGGCGACGCCCAGTCCTGGCTGAACCTTCAGACCGCCTACGACCTGCGC
ACGGCAGAGCTGAACGCGGAGTTGCAGGCGTCCGTGAGGCAAGTTCATCCGATGCAGCTGCATACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References