Detailed information of TA system TA066470

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 4979729..4980338
• Replicon: chromosome
• Accession: NZ_CP017311
• Organism: Hydrogenophaga sp. PBC

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1L1PZY3
• Locus tag: Q5W_RS23715
• Protein ID: WP_009515365.1
• Coordinates: 4979729..4980040 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Q5W_RS23720
• Protein ID: WP_202901790.1
• Coordinates: 4980120..4980338 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5W_RS23690	4975278..4976033	+	756	WP_009515360.1	FadR family transcriptional regulator	-
Q5W_RS23695	4976082..4976720	+	639	WP_009515361.1	LysE family translocator	-
Q5W_RS23700	4977201..4977869	+	669	WP_009515362.1	thioredoxin domain-containing protein	-
Q5W_RS23705	4977903..4978487	+	585	WP_009515363.1	NnrU family protein	-
Q5W_RS23710	4978552..4979682	+	1131	WP_138820322.1	PQQ-dependent sugar dehydrogenase	-
Q5W_RS23715	4979729..4980040	+	312	WP_009515365.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Q5W_RS23720	4980120..4980338	+	219	WP_202901790.1	helix-turn-helix domain-containing protein	Antitoxin
Q5W_RS23725	4980502..4980957	+	456	WP_051756347.1	hypothetical protein	-
Q5W_RS23730	4980980..4981285	+	306	WP_009515367.1	hypothetical protein	-
Q5W_RS23735	4981293..4981811	-	519	WP_081922032.1	transcriptional regulator	-
Q5W_RS23740	4981840..4982271	+	432	WP_009515369.1	hypothetical protein	-
Q5W_RS23745	4982280..4983089	-	810	WP_009515370.1	phosphonate ABC transporter, permease protein PhnE	-
Q5W_RS23750	4983086..4983922	-	837	WP_009515371.1	ABC transporter permease	-
Q5W_RS23755	4983941..4984771	-	831	WP_061285382.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (44-98)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-59)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11576.35 Da
• Isoelectric Point: 9.8315

>T66470 WP_009515365.1 NZ_CP017311:4979729-4980040 [Hydrogenophaga sp. PBC]
MLTVVETLLFQRQWPLYWTEEERGAFVSYIAERPIAGDVVPESGGIRKVRWGRAGSGKSGGVRVIYFTRTAEGEVVLLTM
YAKAKTDNLTGAKLKEIRRALEE

Nucleotide

• Length: 312 bp

>T66470 NZ_CP017311:4979729-4980040 [Hydrogenophaga sp. PBC]
ATGCTCACCGTCGTCGAAACCCTCCTCTTCCAGCGCCAGTGGCCCCTGTACTGGACCGAAGAAGAACGAGGGGCTTTCGT
CAGCTACATCGCGGAGCGCCCCATTGCCGGGGATGTCGTGCCCGAGTCCGGCGGCATTCGAAAAGTCCGTTGGGGACGAG
CAGGTTCGGGCAAGTCGGGTGGTGTTCGGGTGATCTATTTCACTCGCACTGCCGAAGGCGAGGTCGTTTTGCTCACGATG
TATGCCAAGGCAAAAACGGACAACCTCACCGGTGCCAAGTTGAAGGAGATCCGCCGTGCGCTCGAAGAGTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 7542.81 Da
• Isoelectric Point: 12.3622

>AT66470 WP_202901790.1 NZ_CP017311:4980120-4980338 [Hydrogenophaga sp. PBC]
MKAGQLHVVSSPVVEARQKTGLSQSQFAALMGVSVRTLQGWEQGRKQPSGAARTLLAIASMNPKALLAVAGR

Nucleotide

• Length: 219 bp

>AT66470 NZ_CP017311:4980120-4980338 [Hydrogenophaga sp. PBC]
ATGAAAGCGGGCCAGCTTCACGTGGTGTCCTCGCCGGTAGTCGAAGCGCGACAGAAAACGGGGCTTTCCCAATCGCAGTT
CGCTGCACTCATGGGCGTTTCCGTCCGCACCTTGCAAGGCTGGGAACAAGGCCGAAAGCAACCCAGTGGTGCTGCGCGCA
CATTGCTGGCCATTGCCAGCATGAATCCCAAGGCACTGTTGGCTGTCGCCGGTCGGTAG

Structures

Toxin

• AlphaFold DB: A0A1L1PZY3