Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4375534..4376309 Replicon chromosome
Accession NZ_CP017311
Organism Hydrogenophaga sp. PBC

Toxin (Protein)


Gene name yhaV Uniprot ID V6ADY6
Locus tag Q5W_RS20750 Protein ID WP_009518525.1
Coordinates 4375851..4376309 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A1L1PS41
Locus tag Q5W_RS20745 Protein ID WP_009518526.1
Coordinates 4375534..4375851 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5W_RS20735 4371861..4372955 + 1095 WP_009518528.1 lipoprotein signal peptidase -
Q5W_RS25485 4373115..4373327 + 213 WP_158515855.1 integrase core domain-containing protein -
Q5W_RS20740 4373352..4375235 - 1884 WP_009518527.1 TraI domain-containing protein -
Q5W_RS20745 4375534..4375851 + 318 WP_009518526.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
Q5W_RS20750 4375851..4376309 + 459 WP_009518525.1 type II toxin-antitoxin system YhaV family toxin Toxin
Q5W_RS20755 4376336..4376713 + 378 WP_009518524.1 DUF3742 family protein -
Q5W_RS20760 4376729..4378246 - 1518 WP_009518523.1 conjugal transfer protein TraG N-terminal domain-containing protein -
Q5W_RS20765 4378261..4378620 - 360 WP_009518522.1 hypothetical protein -
Q5W_RS20770 4378617..4380011 - 1395 WP_009518521.1 integrating conjugative element protein -
Q5W_RS20775 4380021..4380968 - 948 WP_009518520.1 TIGR03756 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(8-144)

Antitoxin

PrlF antitoxin

(8-100)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17660.02 Da        Isoelectric Point: 10.1848

>T66467 WP_009518525.1 NZ_CP017311:4375851-4376309 [Hydrogenophaga sp. PBC]
MQRHGWTLLFHDCVIEQLQKLHAAARRAQENDPAGFESNANVKLFRALSQLMLDVVPGDPARDEYRQGNTLGPAHRHWRR
AKIGRRFRLFFRYDSKAKVIVYAWVNDEQTLRSSGSKSDPYVVFEKMLGRGNPPDDWHALIQASKQDWSKLE

Download         Length: 459 bp

>T66467 NZ_CP017311:4375851-4376309 [Hydrogenophaga sp. PBC]
ATGCAACGGCATGGCTGGACGCTGCTCTTCCACGACTGCGTGATCGAGCAGTTGCAGAAACTGCATGCGGCCGCGAGGCG
CGCGCAGGAGAATGACCCGGCGGGCTTCGAGTCCAATGCCAACGTCAAGCTCTTCCGGGCCCTGAGCCAGTTGATGTTGG
ATGTGGTGCCAGGCGATCCGGCACGCGACGAGTACCGCCAGGGCAACACCTTGGGACCTGCCCACCGCCACTGGCGAAGG
GCCAAGATCGGAAGGCGGTTCCGGCTGTTCTTCCGGTACGACTCGAAGGCGAAGGTCATTGTGTACGCCTGGGTCAACGA
TGAACAGACCCTGCGGTCTTCGGGTAGCAAATCGGACCCGTATGTCGTGTTCGAGAAGATGCTCGGACGCGGGAACCCAC
CAGACGACTGGCACGCGCTGATACAGGCAAGCAAGCAGGATTGGAGCAAACTGGAATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11156.69 Da        Isoelectric Point: 4.7182

>AT66467 WP_009518526.1 NZ_CP017311:4375534-4375851 [Hydrogenophaga sp. PBC]
MPAIHEVATLTSKGQVTLPKPIRQALGVDAGGKLAFDLRGSEVVVTRVDAEHEDPAIGAFLSLLARDIEAGRNVRGLPED
LARAMLEHAGHGVNLDEEIDGKVEL

Download         Length: 318 bp

>AT66467 NZ_CP017311:4375534-4375851 [Hydrogenophaga sp. PBC]
ATGCCTGCCATCCACGAAGTCGCCACGTTGACCTCCAAGGGCCAGGTCACGCTGCCCAAGCCTATCCGGCAGGCGCTGGG
CGTTGATGCCGGCGGCAAGCTCGCGTTCGATCTGCGGGGCAGCGAAGTCGTCGTCACCCGTGTTGATGCCGAGCACGAGG
ACCCCGCCATTGGCGCGTTTCTGAGCCTGCTGGCCCGCGACATCGAAGCTGGCCGGAACGTCCGGGGCCTGCCCGAGGAT
CTGGCGCGCGCCATGCTGGAGCATGCTGGCCACGGTGTGAACCTGGACGAGGAGATCGACGGGAAAGTGGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ADY6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1PS41

References