Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3734253..3734849 Replicon chromosome
Accession NZ_CP017290
Organism Pseudomonas sp. LPH1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BHQ29_RS17245 Protein ID WP_079784481.1
Coordinates 3734253..3734531 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BHQ29_RS17250 Protein ID WP_079784482.1
Coordinates 3734544..3734849 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHQ29_RS24290 3730026..3731171 + 1146 WP_152029978.1 hypothetical protein -
BHQ29_RS24295 3731382..3732359 + 978 WP_152029979.1 hypothetical protein -
BHQ29_RS17230 3732615..3732887 - 273 WP_079784479.1 DNA-binding protein -
BHQ29_RS17235 3733154..3733654 + 501 WP_079784480.1 hypothetical protein -
BHQ29_RS24490 3733654..3733770 + 117 Protein_3402 ribbon-helix-helix protein, CopG family -
BHQ29_RS24300 3733753..3734064 + 312 WP_202971863.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BHQ29_RS17245 3734253..3734531 + 279 WP_079784481.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BHQ29_RS17250 3734544..3734849 + 306 WP_079784482.1 HigA family addiction module antidote protein Antitoxin
BHQ29_RS24305 3734941..3735111 + 171 WP_152029981.1 YhfG family protein -
BHQ29_RS17255 3735228..3735596 + 369 WP_079784483.1 hypothetical protein -
BHQ29_RS24310 3735994..3736203 + 210 WP_033377562.1 hypothetical protein -
BHQ29_RS24460 3736309..3736473 + 165 WP_165284738.1 hypothetical protein -
BHQ29_RS17265 3736499..3736945 + 447 WP_072422976.1 hypothetical protein -
BHQ29_RS17270 3737166..3738080 - 915 WP_079784484.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10584.04 Da        Isoelectric Point: 8.5556

>T66422 WP_079784481.1 NZ_CP017290:3734253-3734531 [Pseudomonas sp. LPH1]
MILSFRCAETQALFESGSSRRWANILNVATRKLTMLNTAVELRDLRSPPGNRLEQLQGNRADQHSIRINDQWRICFVWTA
AGPTQVEIVDYH

Download         Length: 279 bp

>T66422 NZ_CP017290:3734253-3734531 [Pseudomonas sp. LPH1]
ATGATCCTGAGTTTCAGATGCGCAGAAACCCAGGCTCTGTTTGAGTCAGGAAGCTCCAGACGCTGGGCCAACATTCTCAA
CGTGGCCACGCGGAAGCTGACCATGCTGAATACAGCCGTTGAGCTGCGCGACCTCCGCTCTCCGCCGGGCAACCGGCTGG
AGCAGCTACAGGGCAATCGGGCAGATCAACACAGCATCCGAATCAACGATCAATGGCGAATCTGCTTTGTGTGGACTGCC
GCTGGTCCTACACAAGTCGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11055.62 Da        Isoelectric Point: 4.7616

>AT66422 WP_079784482.1 NZ_CP017290:3734544-3734849 [Pseudomonas sp. LPH1]
MAINGMRPVHPGEVLREEFLEPLGMTPAALARALHVSAPTINDIVRERRGITADTAIRLGRYFDTSAQFWMNLQTEYALA
ATYAESGAAIEQAIEPLQIAS

Download         Length: 306 bp

>AT66422 NZ_CP017290:3734544-3734849 [Pseudomonas sp. LPH1]
ATGGCTATCAACGGCATGCGCCCCGTTCACCCTGGCGAAGTGCTACGCGAAGAGTTTCTTGAGCCGCTGGGAATGACCCC
AGCCGCACTTGCTCGCGCTCTGCATGTGTCGGCGCCGACCATCAATGACATCGTGCGGGAGCGTCGTGGCATTACCGCCG
ATACGGCTATTCGGCTAGGCCGCTACTTCGACACCTCAGCTCAGTTCTGGATGAACTTGCAGACTGAGTATGCACTGGCG
GCAACTTACGCCGAGTCTGGCGCAGCCATCGAGCAGGCCATTGAGCCGCTTCAGATAGCGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References