Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4901..5417 Replicon plasmid pFAM18149.22
Accession NZ_CP017263
Organism Lacticaseibacillus paracasei strain FAM18149

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag FAM18149p_RS14740 Protein ID WP_096836625.1
Coordinates 5136..5417 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag FAM18149p_RS14735 Protein ID WP_016363783.1
Coordinates 4901..5143 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAM18149p_RS14720 471..2150 + 1680 WP_003603889.1 alpha-glucosidase -
FAM18149p_RS14725 2552..3714 + 1163 WP_096836623.1 IS3 family transposase -
FAM18149p_RS14730 4405..4773 + 369 WP_016386228.1 YxeA family protein -
FAM18149p_RS14735 4901..5143 + 243 WP_016363783.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FAM18149p_RS14740 5136..5417 + 282 WP_096836625.1 type II toxin-antitoxin system YafQ family toxin Toxin
FAM18149p_RS14745 5554..5871 + 318 Protein_6 recombinase family protein -
FAM18149p_RS14750 5932..6099 - 168 Protein_7 IS256 family transposase -
FAM18149p_RS14760 6954..7310 + 357 Protein_9 DDE-type integrase/transposase/recombinase -
FAM18149p_RS14765 7547..8497 + 951 WP_096836630.1 magnesium transporter CorA family protein -
FAM18149p_RS14775 8825..9126 + 302 Protein_11 transposase -
FAM18149p_RS14780 9164..9655 + 492 WP_096836632.1 replication protein -
FAM18149p_RS14785 9678..10352 + 675 WP_096836633.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..36931 36931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-62)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11343.88 Da        Isoelectric Point: 8.4074

>T66360 WP_096836625.1 NZ_CP017263:5136-5417 [Lacticaseibacillus paracasei]
MNNFIYKPAFERQFKKHYKTILKGGRYKKEDFEAVYHKLLQDEPLDPHYNDHALVNRKPERDLHIKPDWLLIYKYDGEFV
RFIDTGSHSDLFN

Download         Length: 282 bp

>T66360 NZ_CP017263:5136-5417 [Lacticaseibacillus paracasei]
ATGAATAACTTTATTTACAAACCAGCCTTTGAACGTCAATTTAAAAAACATTACAAGACGATTTTAAAAGGGGGGCGCTA
TAAAAAAGAAGATTTTGAAGCTGTTTATCATAAACTATTACAAGATGAACCGTTAGATCCACATTATAATGATCACGCTT
TGGTTAATCGTAAACCAGAGCGTGATTTACATATCAAGCCGGATTGGTTATTAATTTACAAATATGATGGTGAGTTTGTG
CGCTTTATCGACACGGGTTCGCATTCAGATCTTTTTAATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9217.44 Da        Isoelectric Point: 5.1548

>AT66360 WP_016363783.1 NZ_CP017263:4901-5143 [Lacticaseibacillus paracasei]
MTSQVHFRMSEKEKKDFEIVLSRVGLTPGEAFRIFAKKSIEAGGIPFEVSQPNTRLKKAIRSQDYVEFNDPEEGLDWLNE

Download         Length: 243 bp

>AT66360 NZ_CP017263:4901-5143 [Lacticaseibacillus paracasei]
ATGACTAGCCAAGTACATTTCAGAATGAGCGAAAAAGAAAAAAAGGACTTCGAGATTGTCCTAAGTCGTGTGGGATTAAC
TCCCGGGGAAGCCTTTCGTATCTTTGCCAAGAAATCCATTGAAGCCGGAGGAATTCCCTTTGAGGTCTCTCAGCCAAACA
CACGTTTAAAAAAGGCTATTAGAAGTCAAGATTACGTTGAATTTAACGATCCTGAGGAAGGGCTGGATTGGTTAAATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References