Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 862236..862800 Replicon chromosome
Accession NZ_CP017261
Organism Lacticaseibacillus paracasei strain FAM18149

Toxin (Protein)


Gene name yafQ Uniprot ID K6S2P8
Locus tag FAM18149p_RS04630 Protein ID WP_003602097.1
Coordinates 862498..862800 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag FAM18149p_RS04625 Protein ID WP_003570051.1
Coordinates 862236..862505 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAM18149p_RS04615 860349..861164 + 816 WP_003602094.1 DUF2399 domain-containing protein -
FAM18149p_RS04620 861209..861862 + 654 WP_003602095.1 GNAT family N-acetyltransferase -
FAM18149p_RS04625 862236..862505 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FAM18149p_RS04630 862498..862800 + 303 WP_003602097.1 type II toxin-antitoxin system YafQ family toxin Toxin
FAM18149p_RS04635 863509..864096 + 588 WP_003602101.1 hypothetical protein -
FAM18149p_RS04640 864332..866509 + 2178 WP_003602103.1 RNA-binding transcriptional accessory protein -
FAM18149p_RS04645 866943..867500 - 558 WP_003602105.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11442.21 Da        Isoelectric Point: 9.9697

>T66358 WP_003602097.1 NZ_CP017261:862498-862800 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

>T66358 NZ_CP017261:862498-862800 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTACATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGGTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT66358 WP_003570051.1 NZ_CP017261:862236-862505 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT66358 NZ_CP017261:862236-862505 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAAGAAACTCGCTTGAATATTCGTGTTGATCCGGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K6S2P8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References