Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4709151..4709563 | Replicon | chromosome |
Accession | NZ_CP017251 | ||
Organism | Escherichia coli strain NADC 5570/86-24/6564 isolate wild |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | BHW77_RS24290 | Protein ID | WP_000132630.1 |
Coordinates | 4709222..4709563 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4709151..4709227 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BHW77_RS24280 | 4705778..4707247 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
BHW77_RS24285 | 4707247..4709001 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- | 4709151..4709227 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4709151..4709227 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4709151..4709227 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4709151..4709227 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4709151..4709227 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4709151..4709227 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4709151..4709227 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4709151..4709227 | - | 77 | NuclAT_16 | - | Antitoxin |
BHW77_RS24290 | 4709222..4709563 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
BHW77_RS30560 | 4709610..4710773 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
BHW77_RS24300 | 4710821..4711702 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
BHW77_RS24305 | 4711799..4711963 | - | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
BHW77_RS24310 | 4712140..4713552 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
BHW77_RS32290 | 4713795..4713995 | - | 201 | WP_001310455.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4701350..4722577 | 21227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T66348 WP_000132630.1 NZ_CP017251:4709222-4709563 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T66348 NZ_CP017251:4709222-4709563 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT66348 NZ_CP017251:c4709227-4709151 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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