Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 63735..64381 Replicon chromosome
Accession NZ_CP017181
Organism Enterobacter kobei strain DSM 13645

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BFV64_RS00325 Protein ID WP_032637796.1
Coordinates 64031..64381 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BFV64_RS00320 Protein ID WP_032635284.1
Coordinates 63735..64034 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV64_RS00290 59148..60107 - 960 WP_023333995.1 DUF523 and DUF1722 domain-containing protein -
BFV64_RS00295 60211..60621 - 411 WP_014881954.1 hydroxyisourate hydrolase -
BFV64_RS00300 60721..61446 - 726 WP_045269330.1 MerR family transcriptional regulator -
BFV64_RS00305 61564..62088 + 525 WP_045281336.1 lipocalin family protein -
BFV64_RS00310 62167..63165 + 999 WP_050862777.1 class I SAM-dependent methyltransferase -
BFV64_RS00315 63268..63705 + 438 WP_045281332.1 acetyltransferase -
BFV64_RS00320 63735..64034 - 300 WP_032635284.1 XRE family transcriptional regulator Antitoxin
BFV64_RS00325 64031..64381 - 351 WP_032637796.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFV64_RS00330 64911..65252 - 342 WP_032635286.1 SymE family type I addiction module toxin -
BFV64_RS23875 65383..65586 + 204 WP_071890797.1 toxin-antitoxin system HicB family antitoxin -
BFV64_RS00335 65583..66147 - 565 Protein_68 hypothetical protein -
BFV64_RS00345 66609..68000 + 1392 WP_059373364.1 glycoside-pentoside-hexuronide family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13483.49 Da        Isoelectric Point: 6.9811

>T66154 WP_032637796.1 NZ_CP017181:c64381-64031 [Enterobacter kobei]
MWTVLFGKVFELWLLEQEEGLQEKVLADMLNLQNYGPRLPRPYADTVKGSQYNNMKELRVQYAGRPIRALFAFDPERQAI
VLCAGNKSNDKAFYEKLIRIADDEFTRHLTSLETAK

Download         Length: 351 bp

>T66154 NZ_CP017181:c64381-64031 [Enterobacter kobei]
ATGTGGACGGTACTGTTCGGAAAGGTGTTTGAGCTATGGTTGCTTGAACAGGAAGAAGGGTTACAGGAAAAGGTACTGGC
AGACATGCTAAATCTACAAAACTATGGACCTCGTCTTCCTCGTCCCTATGCCGATACTGTAAAAGGCTCGCAATATAACA
ATATGAAAGAGTTACGTGTTCAATACGCTGGTCGTCCGATTCGTGCTTTATTCGCATTTGACCCCGAACGTCAGGCGATT
GTGCTTTGCGCAGGCAACAAGAGTAACGACAAGGCATTTTATGAAAAACTCATTCGCATTGCAGATGATGAATTTACCCG
GCATCTGACAAGCCTGGAGACAGCCAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11160.04 Da        Isoelectric Point: 6.9842

>AT66154 WP_032635284.1 NZ_CP017181:c64034-63735 [Enterobacter kobei]
VKTLNELIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKNVAELMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp

>AT66154 NZ_CP017181:c64034-63735 [Enterobacter kobei]
GTGAAAACACTAAATGAATTAATTGCATCACGCTCACCGGAAAGCCAACAACGAATTAAAGAAATGGCAGAGGAAATGAT
CCTTGAAACGGGTTTGCAACTTTTACGTGAAGAGCTCAGGCTTTCGCAAAAAAATGTTGCCGAGCTAATGGGGGTGAGCC
AGCCCGCAGTAACACAAATAGAGCAACGTGGAAATGAACTAAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGT
GGGAAACTTTGTATCGACGTTGAACTTCCAACAGGAAAACGCGTTGCGTTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References