Detailed information of TA system TA066093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2530962..2531617
• Replicon: chromosome
• Accession: NZ_CP017158
• Organism: Bordetella pertussis strain J165

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BHR56_RS12225
• Protein ID: WP_047122780.1
• Coordinates: 2531366..2531617 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: BHR56_RS12220
• Protein ID: WP_003809516.1
• Coordinates: 2530962..2531363 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BHR56_RS12190	2526145..2527167	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
BHR56_RS12195	2527304..2528341	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
BHR56_RS12200	2528361..2529551	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BHR56_RS12205	2529554..2530069	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BHR56_RS12210	2530219..2530698	-	480	WP_010930405.1	disulfide bond formation protein B	-
BHR56_RS12215	2530706..2530942	-	237	WP_010930404.1	membrane protein	-
BHR56_RS12220	2530962..2531363	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BHR56_RS12225	2531366..2531617	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BHR56_RS12230	2531672..2532553	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
BHR56_RS12235	2532778..2533224	+	447	WP_003819827.1	GFA family protein	-
BHR56_RS12240	2533309..2534373	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
BHR56_RS12245	2534510..2535091	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
BHR56_RS12250	2535326..2536456	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T66093 WP_047122780.1 NZ_CP017158:c2531617-2531366 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T66093 NZ_CP017158:c2531617-2531366 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT66093 WP_003809516.1 NZ_CP017158:c2531363-2530962 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT66093 NZ_CP017158:c2531363-2530962 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6