Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 758616..759138 Replicon chromosome
Accession NZ_CP017156
Organism Macrococcus sp. IME1552

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag BHM04_RS04085 Protein ID WP_096076548.1
Coordinates 758866..759138 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag BHM04_RS04080 Protein ID WP_096076547.1
Coordinates 758616..758873 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHM04_RS04060 753675..754142 - 468 WP_096076543.1 hypothetical protein -
BHM04_RS04065 754265..755878 - 1614 WP_096076544.1 ABC-F type ribosomal protection protein -
BHM04_RS04070 756285..756779 - 495 WP_157742183.1 cysteine hydrolase -
BHM04_RS04075 757312..758484 + 1173 WP_096076546.1 MFS transporter -
BHM04_RS04080 758616..758873 + 258 WP_096076547.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BHM04_RS04085 758866..759138 + 273 WP_096076548.1 Txe/YoeB family addiction module toxin Toxin
BHM04_RS04090 759139..760032 - 894 WP_096076549.1 phosphotransferase -
BHM04_RS04095 760042..760782 - 741 WP_096076550.1 hypothetical protein -
BHM04_RS04100 760865..761311 + 447 WP_096076551.1 GNAT family N-acetyltransferase -
BHM04_RS04105 761348..761599 - 252 WP_096076552.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BHM04_RS04110 761670..762917 - 1248 WP_096076553.1 putative DNA binding domain-containing protein -
BHM04_RS04115 763021..763875 - 855 WP_096076554.1 DUF4240 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10561.30 Da        Isoelectric Point: 9.9500

>T66090 WP_096076548.1 NZ_CP017156:758866-759138 [Macrococcus sp. IME1552]
MPKKKILFNSSGFEDYTYWQTKDKTVSKKINKLIKSIMIDGANVGIGKPEKLLGNYTGCYSRRITHEHRIVYKIEDDSIC
ILQCRFHYKN

Download         Length: 273 bp

>T66090 NZ_CP017156:758866-759138 [Macrococcus sp. IME1552]
ATGCCTAAGAAAAAGATACTATTTAATTCAAGTGGTTTTGAAGATTATACGTACTGGCAAACTAAAGATAAAACTGTATC
AAAGAAAATAAATAAACTAATAAAGAGTATTATGATTGATGGTGCAAATGTAGGTATAGGTAAGCCAGAAAAATTATTAG
GAAACTATACAGGTTGCTATAGCAGAAGGATCACTCATGAACATAGGATCGTATATAAGATAGAAGATGATTCCATTTGT
ATTTTACAATGTCGTTTTCATTACAAAAATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9718.81 Da        Isoelectric Point: 4.2805

>AT66090 WP_096076547.1 NZ_CP017156:758616-758873 [Macrococcus sp. IME1552]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEHDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT66090 NZ_CP017156:758616-758873 [Macrococcus sp. IME1552]
ATGAAAGTAACAACTTATTCTAATGCAAGATCAAATTTTAGAAAAATTATAGATATTGTTAATGAAGACTGTGAACCTTA
CACTATCACGACAAACACGCATAATGCAGTGATATTATCTGAGCATGACTATAATAGTATGATTGAAACACTTTATTTAC
AGAGTACACCTGCGAATGCCGAAAGATTACAAAAAGCGATTGATGAATCAATTGATAAAAATAACTTACTTCAAGTTGAG
ATTGATTTAGATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References