Detailed information of TA system TA066035

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1547125..1547704
• Replicon: chromosome
• Accession: NZ_CP017115
• Organism: Staphylococcus aureus strain FORC_045

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FORC45_RS07790
• Protein ID: WP_001025401.1
• Coordinates: 1547459..1547704 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1547125..1547490 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC45_RS07750	1543868..1544425	-	558	WP_000645048.1	DUF2815 family protein	-
FORC45_RS07755	1544451..1545617	-	1167	WP_088607383.1	DUF2800 domain-containing protein	-
FORC45_RS07760	1545614..1545976	-	363	WP_000985986.1	hypothetical protein	-
FORC45_RS07765	1545991..1546314	-	324	WP_000175000.1	hypothetical protein	-
FORC45_RS07770	1546393..1546554	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
FORC45_RS07775	1546567..1546830	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
FORC45_RS07780	1546855..1547070	-	216	WP_001097552.1	hypothetical protein	-
FORC45_RS07785	1547125..1547490	+	366	WP_001128433.1	hypothetical protein	Antitoxin
FORC45_RS07790	1547459..1547704	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FORC45_RS07795	1547760..1547969	+	210	WP_000642492.1	hypothetical protein	-
FORC45_RS07800	1547959..1548102	-	144	WP_000939498.1	hypothetical protein	-
FORC45_RS07805	1548117..1548560	-	444	WP_000435360.1	hypothetical protein	-
FORC45_RS07810	1548578..1548802	-	225	WP_000333485.1	DUF739 family protein	-
FORC45_RS07815	1548964..1549344	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
FORC45_RS07820	1549366..1549824	+	459	WP_001558059.1	hypothetical protein	-
FORC45_RS07825	1549842..1550276	+	435	WP_000755719.1	hypothetical protein	-
FORC45_RS07830	1550305..1550700	+	396	WP_000449655.1	hypothetical protein	-
FORC45_RS07835	1550790..1550936	+	147	WP_001013104.1	hypothetical protein	-
FORC45_RS07840	1550933..1551547	-	615	WP_088607384.1	ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp	1500761..1570505	69744

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T66035 WP_001025401.1 NZ_CP017115:c1547704-1547459 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T66035 NZ_CP017115:c1547704-1547459 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT66035 NZ_CP017115:1547125-1547490 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin