Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2058399..2059036 Replicon chromosome
Accession NZ_CP017114
Organism Cobetia marina strain JCM 21022

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BFX80_RS08735 Protein ID WP_084209703.1
Coordinates 2058399..2058692 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BFX80_RS08740 Protein ID WP_077376121.1
Coordinates 2058707..2059036 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFX80_RS08725 2053929..2056379 + 2451 WP_084208608.1 FdhF/YdeP family oxidoreductase -
BFX80_RS08730 2056927..2058228 + 1302 WP_084208609.1 cytosine permease -
BFX80_RS08735 2058399..2058692 + 294 WP_084209703.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFX80_RS08740 2058707..2059036 + 330 WP_077376121.1 HigA family addiction module antidote protein Antitoxin
BFX80_RS08745 2059163..2060125 - 963 WP_205632776.1 EamA family transporter -
BFX80_RS08750 2060329..2061549 - 1221 WP_084208611.1 DMT family transporter -
BFX80_RS08755 2061726..2062457 - 732 WP_084208612.1 AraC family transcriptional regulator -
BFX80_RS08760 2062532..2063074 - 543 WP_077376133.1 hypothetical protein -
BFX80_RS08765 2063394..2063978 + 585 WP_084208613.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11204.66 Da        Isoelectric Point: 7.3556

>T66032 WP_084209703.1 NZ_CP017114:2058399-2058692 [Cobetia marina]
MAVEFRDVWLESFYEQDVGHRKIPAALSSSLYRKLQILDAASQESDLRIPPGNRFEHLQGNLAGYCSIRVNKQYRLIFRW
EAGIAHQTYLDPHADKG

Download         Length: 294 bp

>T66032 NZ_CP017114:2058399-2058692 [Cobetia marina]
ATGGCGGTGGAATTCAGGGATGTGTGGCTCGAGAGCTTCTACGAGCAAGATGTTGGCCACCGCAAGATACCTGCGGCGCT
CTCAAGTTCGCTTTATCGCAAGTTGCAGATTCTCGATGCCGCAAGCCAGGAGTCTGATTTGAGGATTCCGCCAGGCAATC
GTTTCGAGCATCTCCAGGGCAATCTCGCAGGTTATTGCTCGATTCGCGTCAACAAGCAGTATCGACTCATCTTTCGATGG
GAGGCAGGGATTGCCCATCAAACATATCTAGACCCGCATGCTGACAAGGGCTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12252.11 Da        Isoelectric Point: 7.4713

>AT66032 WP_077376121.1 NZ_CP017114:2058707-2059036 [Cobetia marina]
MRNTQRRPLTVGEMLTAEFLEPMEIDIRTLAEAMGVHRNTLSRIVHDKGTLTAPMAIKLAAALGNTPEFWLNIQHAVELW
DVRHRAYAQDAKGVRRITPQVDAAELASH

Download         Length: 330 bp

>AT66032 NZ_CP017114:2058707-2059036 [Cobetia marina]
ATGAGAAACACCCAGCGGCGCCCACTGACGGTAGGCGAGATGTTGACGGCAGAGTTTCTGGAGCCGATGGAGATCGACAT
CCGCACACTGGCCGAGGCGATGGGAGTGCACAGAAATACCCTGAGCCGTATCGTTCATGACAAGGGGACCTTGACGGCCC
CGATGGCCATCAAGCTGGCGGCTGCGCTAGGCAATACGCCGGAGTTTTGGCTCAACATCCAGCATGCTGTGGAGCTCTGG
GATGTGCGTCATCGTGCCTACGCGCAGGATGCCAAGGGCGTACGTCGCATAACGCCGCAAGTTGATGCCGCCGAGCTTGC
CTCGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References