Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3640526..3640748 Replicon chromosome
Accession NZ_CP017100
Organism Escherichia coli strain K-12 NEB 5-alpha

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag NEB5A_RS18105 Protein ID WP_000141634.1
Coordinates 3640526..3640633 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3640682..3640748 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NEB5A_RS18080 3635779..3636531 - 753 Protein_3465 cellulose biosynthesis protein BcsQ -
NEB5A_RS18085 3636543..3636731 - 189 WP_001063318.1 YhjR family protein -
NEB5A_RS18090 3637004..3638575 + 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
NEB5A_RS18095 3638572..3638763 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
NEB5A_RS18100 3638760..3640439 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
NEB5A_RS18105 3640526..3640633 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 3640682..3640748 + 67 - - Antitoxin
NEB5A_RS18115 3641109..3642380 + 1272 WP_001295225.1 transporter -
NEB5A_RS18120 3642410..3643414 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
NEB5A_RS18125 3643411..3644394 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
NEB5A_RS18130 3644405..3645307 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T65996 WP_000141634.1 NZ_CP017100:c3640633-3640526 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T65996 NZ_CP017100:c3640633-3640526 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT65996 NZ_CP017100:3640682-3640748 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References