Detailed information of TA system TA065952

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2836949..2837287
• Replicon: chromosome
• Accession: NZ_CP017094
• Organism: Staphylococcus aureus strain 2148.C01

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: A7U45_RS14860
• Protein ID: WP_011447039.1
• Coordinates: 2836949..2837125 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2837113..2837287 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7U45_RS14840	2832184..2835969	+	3786	WP_000582165.1	hypothetical protein	-
A7U45_RS14845	2835959..2836111	+	153	WP_001153681.1	hypothetical protein	-
A7U45_RS14850	2836158..2836445	+	288	WP_001040261.1	hypothetical protein	-
A7U45_RS14855	2836503..2836799	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
A7U45_RS14860	2836949..2837125	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2837113..2837287	-	175	-	-	Antitoxin
A7U45_RS14870	2837337..2837591	+	255	WP_000611512.1	phage holin	-
A7U45_RS14875	2837603..2838358	+	756	WP_000861038.1	CHAP domain-containing protein	-
A7U45_RS14880	2838549..2839040	+	492	WP_000919350.1	staphylokinase	-
A7U45_RS14890	2839690..2840025	+	336	Protein_2757	SH3 domain-containing protein	-
A7U45_RS14895	2840120..2840569	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
A7U45_RS14900	2841254..2841604	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
A7U45_RS14905	2841657..2841917	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2785668..2841604	55936

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T65952 WP_011447039.1 NZ_CP017094:2836949-2837125 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T65952 NZ_CP017094:2836949-2837125 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT65952 NZ_CP017094:c2837287-2837113 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin