Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2662376..2662639 Replicon chromosome
Accession NZ_CP017094
Organism Staphylococcus aureus strain 2148.C01

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag A7U45_RS13840 Protein ID WP_001802298.1
Coordinates 2662376..2662480 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2662475..2662639 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U45_RS13815 2657760..2658542 + 783 WP_000908176.1 ABC transporter ATP-binding protein -
A7U45_RS13820 2658610..2659467 + 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
A7U45_RS13825 2660172..2660264 - 93 WP_001790138.1 hypothetical protein -
A7U45_RS13830 2660553..2661689 + 1137 WP_000115564.1 SAP domain-containing protein -
A7U45_RS15250 2661732..2662215 + 484 Protein_2558 recombinase family protein -
A7U45_RS13840 2662376..2662480 + 105 WP_001802298.1 hypothetical protein Toxin
- 2662475..2662639 - 165 - - Antitoxin
A7U45_RS13845 2662980..2664071 - 1092 WP_000495671.1 lytic regulatory protein -
A7U45_RS13850 2664337..2665317 - 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
A7U45_RS13855 2665319..2665639 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
A7U45_RS13860 2665791..2666456 + 666 WP_001024094.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T65946 WP_001802298.1 NZ_CP017094:2662376-2662480 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T65946 NZ_CP017094:2662376-2662480 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT65946 NZ_CP017094:c2662639-2662475 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References