Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2395811..2396328 Replicon chromosome
Accession NZ_CP017094
Organism Staphylococcus aureus strain 2148.C01

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag A7U45_RS12405 Protein ID WP_000113262.1
Coordinates 2396062..2396328 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag A7U45_RS12400 Protein ID WP_000584502.1
Coordinates 2395811..2396062 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U45_RS12370 2391512..2392231 + 720 WP_000479576.1 amino acid ABC transporter permease -
A7U45_RS12375 2392228..2392959 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
A7U45_RS12380 2393056..2394306 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
A7U45_RS12385 2394561..2394920 + 360 WP_000819847.1 DUF4467 domain-containing protein -
A7U45_RS12390 2394939..2395538 + 600 WP_000162813.1 DsbA family protein -
A7U45_RS12395 2395545..2395646 + 102 WP_001791744.1 hypothetical protein -
A7U45_RS12400 2395811..2396062 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7U45_RS12405 2396062..2396328 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
A7U45_RS12410 2396363..2396434 + 72 Protein_2292 hypothetical protein -
A7U45_RS12415 2396623..2398173 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
A7U45_RS12420 2398359..2398826 + 468 WP_000153344.1 SRPBCC domain-containing protein -
A7U45_RS12425 2398910..2399092 + 183 WP_000230294.1 hypothetical protein -
A7U45_RS12430 2399309..2400133 + 825 WP_000572040.1 formate/nitrite transporter family protein -
A7U45_RS12435 2400366..2400902 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T65945 WP_000113262.1 NZ_CP017094:2396062-2396328 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T65945 NZ_CP017094:2396062-2396328 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT65945 WP_000584502.1 NZ_CP017094:2395811-2396062 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT65945 NZ_CP017094:2395811-2396062 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References