Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2370796..2370980 Replicon chromosome
Accession NZ_CP017094
Organism Staphylococcus aureus strain 2148.C01

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag A7U45_RS12245 Protein ID WP_000482650.1
Coordinates 2370796..2370903 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2370920..2370980 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U45_RS12220 2366158..2366631 + 474 WP_000456489.1 GyrI-like domain-containing protein -
A7U45_RS12225 2366754..2367965 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
A7U45_RS12230 2368147..2368806 - 660 WP_000831298.1 membrane protein -
A7U45_RS12235 2368866..2370008 - 1143 WP_001176863.1 glycerate kinase -
A7U45_RS12240 2370276..2370662 + 387 WP_000779358.1 flippase GtxA -
A7U45_RS12245 2370796..2370903 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2370920..2370980 - 61 - - Antitoxin
A7U45_RS12255 2371531..2373294 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
A7U45_RS12260 2373319..2375052 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
A7U45_RS12270 2375283..2375450 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T65943 WP_000482650.1 NZ_CP017094:2370796-2370903 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T65943 NZ_CP017094:2370796-2370903 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT65943 NZ_CP017094:c2370980-2370920 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References