Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2338957..2339480 Replicon chromosome
Accession NZ_CP017094
Organism Staphylococcus aureus strain 2148.C01

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag A7U45_RS12085 Protein ID WP_000074048.1
Coordinates 2339214..2339480 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag A7U45_RS12080 Protein ID WP_000587616.1
Coordinates 2338957..2339214 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U45_RS12055 2334037..2335230 + 1194 WP_000675401.1 MFS transporter -
A7U45_RS12060 2335454..2336203 - 750 WP_000072444.1 hypothetical protein -
A7U45_RS12065 2336398..2337975 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
A7U45_RS12070 2338143..2338598 - 456 WP_000732082.1 DUF1307 domain-containing protein -
A7U45_RS12080 2338957..2339214 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7U45_RS12085 2339214..2339480 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
A7U45_RS12090 2339835..2340911 + 1077 WP_001076671.1 M42 family metallopeptidase -
A7U45_RS12095 2341159..2341821 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
A7U45_RS12100 2341814..2342590 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
A7U45_RS12105 2342986..2344173 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T65942 WP_000074048.1 NZ_CP017094:2339214-2339480 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T65942 NZ_CP017094:2339214-2339480 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT65942 WP_000587616.1 NZ_CP017094:2338957-2339214 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT65942 NZ_CP017094:2338957-2339214 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References