Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2227301..2227564 Replicon chromosome
Accession NZ_CP017091
Organism Staphylococcus aureus strain ISU926 isolate ST398

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag A2U18_RS11520 Protein ID WP_001802298.1
Coordinates 2227460..2227564 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2227301..2227465 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U18_RS11500 2223486..2224151 - 666 WP_001024099.1 SDR family oxidoreductase -
A2U18_RS11505 2224303..2224623 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
A2U18_RS11510 2224625..2225605 + 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
A2U18_RS11515 2225871..2226962 + 1092 WP_000495673.1 hypothetical protein -
- 2227301..2227465 + 165 - - Antitoxin
A2U18_RS11520 2227460..2227564 - 105 WP_001802298.1 hypothetical protein Toxin
A2U18_RS11530 2228244..2228402 + 159 WP_001792784.1 hypothetical protein -
A2U18_RS11535 2228838..2228930 + 93 WP_000220902.1 hypothetical protein -
A2U18_RS11540 2229060..2229917 - 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
A2U18_RS11545 2229985..2230767 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
A2U18_RS11550 2231057..2231665 - 609 WP_000101714.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T65934 WP_001802298.1 NZ_CP017091:c2227564-2227460 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T65934 NZ_CP017091:c2227564-2227460 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT65934 NZ_CP017091:2227301-2227465 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References