Detailed information of TA system TA065927

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1583036..1583615
• Replicon: chromosome
• Accession: NZ_CP017091
• Organism: Staphylococcus aureus strain ISU926 isolate ST398

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: A2U18_RS07890
• Protein ID: WP_001025401.1
• Coordinates: 1583370..1583615 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1583036..1583401 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A2U18_RS07850	1579779..1580336	-	558	WP_000645049.1	DUF2815 family protein	-
A2U18_RS07855	1580362..1581528	-	1167	WP_031912443.1	DUF2800 domain-containing protein	-
A2U18_RS07860	1581525..1581887	-	363	WP_071938163.1	hypothetical protein	-
A2U18_RS07865	1581902..1582225	-	324	WP_000174994.1	hypothetical protein	-
A2U18_RS07870	1582304..1582465	-	162	WP_001285955.1	DUF1270 family protein	-
A2U18_RS07875	1582478..1582741	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
A2U18_RS07880	1582766..1582981	-	216	WP_001097552.1	hypothetical protein	-
A2U18_RS07885	1583036..1583401	+	366	WP_001128433.1	hypothetical protein	Antitoxin
A2U18_RS07890	1583370..1583615	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
A2U18_RS07895	1583682..1584062	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
A2U18_RS07900	1584049..1584246	-	198	WP_001148860.1	hypothetical protein	-
A2U18_RS07905	1584316..1584528	+	213	WP_000362644.1	hypothetical protein	-
A2U18_RS14730	1584569..1584718	-	150	WP_000771849.1	hypothetical protein	-
A2U18_RS07910	1584774..1584983	+	210	WP_000642492.1	hypothetical protein	-
A2U18_RS07915	1584973..1585116	-	144	WP_000939498.1	hypothetical protein	-
A2U18_RS07920	1585132..1585380	-	249	WP_000272860.1	helix-turn-helix domain-containing protein	-
A2U18_RS07925	1585544..1585873	+	330	WP_071938164.1	helix-turn-helix domain-containing protein	-
A2U18_RS07930	1585886..1586347	+	462	WP_088445687.1	toxin	-
A2U18_RS07935	1586365..1586949	+	585	WP_000825948.1	hypothetical protein	-
A2U18_RS07940	1587179..1587325	+	147	WP_078099401.1	hypothetical protein	-
A2U18_RS07945	1587322..1587936	-	615	WP_000191458.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1542134..1602023	59889

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T65927 WP_001025401.1 NZ_CP017091:c1583615-1583370 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T65927 NZ_CP017091:c1583615-1583370 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT65927 NZ_CP017091:1583036-1583401 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin