Detailed information of TA system TA065926

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1015076..1015325
• Replicon: chromosome
• Accession: NZ_CP017091
• Organism: Staphylococcus aureus strain ISU926 isolate ST398

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: A2U18_RS05065
• Protein ID: WP_000623369.1
• Coordinates: 1015076..1015183 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1015178..1015325 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A2U18_RS05040	1011750..1012319	-	570	WP_000287265.1	competence protein ComK	-
A2U18_RS05045	1012529..1012747	+	219	WP_000876826.1	IDEAL domain-containing protein	-
A2U18_RS05050	1012828..1013814	-	987	WP_000668814.1	lipoate--protein ligase	-
A2U18_RS05055	1014013..1014189	+	177	WP_000214898.1	YkvS family protein	-
A2U18_RS05060	1014204..1014806	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
A2U18_RS05065	1015076..1015183	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	1015178..1015325	-	148	-	-	Antitoxin
A2U18_RS05070	1015818..1016102	+	285	WP_000790905.1	lactococcin 972 family bacteriocin	-
A2U18_RS05075	1016146..1018110	+	1965	WP_000870811.1	bacteriocin-associated integral membrane family protein	-
A2U18_RS05080	1018113..1018433	+	321	WP_000668623.1	YxeA family protein	-
A2U18_RS05085	1018430..1019071	+	642	WP_000571192.1	ABC transporter ATP-binding protein	-
A2U18_RS05090	1019159..1019449	-	291	WP_001796515.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T65926 WP_000623369.1 NZ_CP017091:1015076-1015183 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T65926 NZ_CP017091:1015076-1015183 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT65926 NZ_CP017091:c1015325-1015178 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTGCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin