65922

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2546035..2546219 Replicon chromosome
Accession NZ_CP017090
Organism Staphylococcus aureus strain ISU935 isolate ST5

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag A2V17_RS13165 Protein ID WP_000482652.1
Coordinates 2546112..2546219 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2546035..2546095 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2V17_RS13140 2541490..2541657 - 168 Protein_2450 hypothetical protein -
A2V17_RS13150 2541888..2543621 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
A2V17_RS13155 2543646..2545409 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2546035..2546095 + 61 - - Antitoxin
A2V17_RS13165 2546112..2546219 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
A2V17_RS13170 2546353..2546739 - 387 WP_000779360.1 flippase GtxA -
A2V17_RS13175 2547007..2548149 + 1143 WP_001176863.1 glycerate kinase -
A2V17_RS13180 2548209..2548868 + 660 WP_088401739.1 hypothetical protein -
A2V17_RS13185 2549050..2550261 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
A2V17_RS13190 2550384..2550857 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T65922 WP_000482652.1 NZ_CP017090:c2546219-2546112 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T65922 NZ_CP017090:c2546219-2546112 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT65922 NZ_CP017090:2546035-2546095 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References