Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2245727..2245989 Replicon chromosome
Accession NZ_CP017090
Organism Staphylococcus aureus strain ISU935 isolate ST5

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag A2V17_RS11530 Protein ID WP_001802298.1
Coordinates 2245885..2245989 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2245727..2245890 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2V17_RS11510 2241979..2242644 - 666 WP_001024095.1 SDR family oxidoreductase -
A2V17_RS11515 2242796..2243116 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
A2V17_RS11520 2243118..2244095 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
A2V17_RS11525 2244361..2245452 + 1092 WP_000495669.1 hypothetical protein -
- 2245727..2245890 + 164 - - Antitoxin
A2V17_RS11530 2245885..2245989 - 105 WP_001802298.1 hypothetical protein Toxin
A2V17_RS14855 2246506..2246676 + 171 WP_001792292.1 transposase -
A2V17_RS11540 2246669..2246827 + 159 WP_001792784.1 hypothetical protein -
A2V17_RS11550 2247485..2248342 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
A2V17_RS11555 2248410..2249189 - 780 WP_088401732.1 ABC transporter ATP-binding protein -
A2V17_RS11560 2249695..2250507 - 813 WP_011867740.1 undecaprenyl-diphosphate phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T65920 WP_001802298.1 NZ_CP017090:c2245989-2245885 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T65920 NZ_CP017090:c2245989-2245885 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT65920 NZ_CP017090:2245727-2245890 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References